Histopathological and immunohistochemical features of 32 cases of splenic B-cell lymphoma and leukemia
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2009
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Abstract
Objective: Leukemias and non-Hodgkin lymphomas commonly involve the spleen or originate primarily in the spleen and then spread to other sites. Material and Methods: In this retrospective study, we examined the histopathological and immunohistochemical characteristics of 32 cases of primary or secondary splenic B-cell lymphoma and leukemia, in which the diagnosis was established according to the World Health Organization (WHO) classification. The immunohistochemical panel included ALK-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD30, CD43, cyclin D1, Ki-67, and TRAP. Results: There was no other nodal or extranodal disease involvement in the majority of patients diagnosed with lymphoma at the time of presentation, while cases of leukemia had undergone splenectomy for palliative purposes. The diagnoses were as follows: 11 cases of hairy cell leukemia (HCL, 34.4%), 8 cases of splenic marginal zone lymphoma (SMZL, 25%), 8 cases of diffuse large B-cell lymphoma (DLBCL, 25%) including 1 T-cell-rich B-cell lymphoma (TCRBCL), 4 cases of mantle cell lymphoma (MCL, 12.5%), and 1 prolymphocytic leukemia (PLL, 3.1%). Conclusion: Overall assessment of spleen, liver, bone marrow, and lymph node examinations and a detailed correlation of the histopathological and immunohistochemical features with the clinical findings are very helpful and usually lead to the final diagnosis in most cases of primary or secondary splenic B-cell lymphoma and leukemia. Copyright © 2009 by Türkiye Klinikleri.
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activin receptor like kinase 1 , CD20 antigen , CD23 antigen , CD3 antigen , CD30 antigen , CD5 antigen , common acute lymphoblastic leukemia antigen , complement component C3d receptor , cyclin D1 , fludarabine , Ki 67 antigen , leukosialin , protein bcl 2 , protein bcl 6 , adult , aged , article , B cell lymphoma , bone marrow , cancer classification , cancer diagnosis , cancer palliative therapy , clinical article , clinical assessment , controlled study , female , hairy cell leukemia , histopathology , human , human tissue , immunohistochemistry , large cell lymphoma , leukemia , liver , lymph node , lymph node metastasis , male , mantle cell lymphoma , prolymphocytic leukemia , retrospective study , spleen , splenectomy , splenic b cell lymphoma , splenic leukemia , splenic marginal zone lymphoma , t cell rich b cell lymphoma , world health organization