Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein

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dc.contributor.authorKoç S.
dc.contributor.authorŞen S.
dc.contributor.authorTerzi Y.
dc.contributor.authorKızılay F.
dc.contributor.authorDemir S.
dc.contributor.authorBekar Aksoy D.
dc.contributor.authorKurtuluş F.
dc.contributor.authorBilge N.
dc.contributor.authorIdilman E.
dc.contributor.authorUzunköprü C.
dc.contributor.authorGüngör S.
dc.contributor.authorÇilingir V.
dc.contributor.authorEthemoğlu Ö.
dc.contributor.authorBoz C.
dc.contributor.authorGümüş H.
dc.contributor.authorKılıç A.K.
dc.contributor.authorKısabay A.
dc.contributor.authorBir L.S.
dc.contributor.authorTuran ÖF.
dc.contributor.authorSoysal A.
dc.contributor.authorKöseoğlu M.
dc.contributor.authorTekgöl Uzuner G.
dc.contributor.authorBayındır H.
dc.contributor.authorCanbaz Kabay S.
dc.contributor.authorÇam M.
dc.contributor.authorYayla V.
dc.contributor.authorTan H.
dc.contributor.authorÖzcan A.
dc.contributor.authorTaşkapıoğlu Ö.
dc.contributor.authorKorkmaz M.
dc.contributor.authorTamam Y.
dc.contributor.authorİnanç Y.
dc.contributor.authorEfendi H.
dc.contributor.authorKotan D.
dc.contributor.authorYetkin M.F.
dc.contributor.authorBilgiç A.B.
dc.contributor.authorSaçmacı H.
dc.contributor.authorDemirci S.
dc.contributor.authorÇelik Y.
dc.contributor.authorPoyraz T.
dc.contributor.authorTerzi M.
dc.date.accessioned2024-07-22T08:01:05Z
dc.date.available2024-07-22T08:01:05Z
dc.date.issued2024
dc.description.abstractBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.
dc.identifier.DOI-ID10.4274/balkanmedj.galenos.2024.2024-1-97
dc.identifier.issn21463131
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11317
dc.language.isoEnglish
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAutoantibodies
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultiple Sclerosis
dc.subjectMyelin-Oligodendrocyte Glycoprotein
dc.subjectNeuromyelitis Optica
dc.subjectOptic Neuritis
dc.subjectRetrospective Studies
dc.subjectautoantibody
dc.subjectimmunoglobulin G
dc.subjectmyelin oligodendrocyte glycoprotein
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectblood
dc.subjectclinical trial
dc.subjectdiagnostic imaging
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectmultiple sclerosis
dc.subjectmyelooptic neuropathy
dc.subjectoptic neuritis
dc.subjectretrospective study
dc.titleClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
dc.typeArticle

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