Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders
| dc.contributor.author | Sota J. | |
| dc.contributor.author | Guerriero S. | |
| dc.contributor.author | Lopalco G. | |
| dc.contributor.author | Tufan A. | |
| dc.contributor.author | Ragab G. | |
| dc.contributor.author | AlMaglouth I. | |
| dc.contributor.author | Govoni M. | |
| dc.contributor.author | Sfikakis P.P. | |
| dc.contributor.author | Frassi M. | |
| dc.contributor.author | Vitale A. | |
| dc.contributor.author | Kardas R.C. | |
| dc.contributor.author | Triaggianese P. | |
| dc.contributor.author | Chimenti M.S. | |
| dc.contributor.author | Aboabat A.A. | |
| dc.contributor.author | Piga M. | |
| dc.contributor.author | Monti S. | |
| dc.contributor.author | Sebastiani G.D. | |
| dc.contributor.author | Yildirim D. | |
| dc.contributor.author | Conforti A. | |
| dc.contributor.author | Gentileschi S. | |
| dc.contributor.author | Dammacco R. | |
| dc.contributor.author | Hinojosa-Azaola A. | |
| dc.contributor.author | Kawakami-Campos P.A. | |
| dc.contributor.author | Ruffilli F. | |
| dc.contributor.author | Torres-Ruiz J. | |
| dc.contributor.author | Thabet M. | |
| dc.contributor.author | Atig A. | |
| dc.contributor.author | Ruscitti P. | |
| dc.contributor.author | Cataldi G. | |
| dc.contributor.author | Viapiana O. | |
| dc.contributor.author | Hatemi G. | |
| dc.contributor.author | Karakoç A. | |
| dc.contributor.author | Costi S. | |
| dc.contributor.author | Iagnocco A. | |
| dc.contributor.author | Crisafulli F. | |
| dc.contributor.author | Fragoulis G. | |
| dc.contributor.author | Del Giudice E. | |
| dc.contributor.author | Hegazy M.T. | |
| dc.contributor.author | Paroli M.P. | |
| dc.contributor.author | Şahin A. | |
| dc.contributor.author | Morrone M. | |
| dc.contributor.author | Iannone F. | |
| dc.contributor.author | Opris-Belinski D. | |
| dc.contributor.author | Asfina K.N. | |
| dc.contributor.author | Barone P. | |
| dc.contributor.author | Gaggiano C. | |
| dc.contributor.author | Kucuk H. | |
| dc.contributor.author | Gicchino M.F. | |
| dc.contributor.author | Carubbi F. | |
| dc.contributor.author | Caggiano V. | |
| dc.contributor.author | Laskari K. | |
| dc.contributor.author | Tharwat S. | |
| dc.contributor.author | Direskeneli H. | |
| dc.contributor.author | Alibaz-Oner F. | |
| dc.contributor.author | Sevik G. | |
| dc.contributor.author | Maier A. | |
| dc.contributor.author | Laymouna A.H. | |
| dc.contributor.author | Emmi G. | |
| dc.contributor.author | Akkoç N. | |
| dc.contributor.author | Tarsia M. | |
| dc.contributor.author | Sbalchiero J. | |
| dc.contributor.author | Conti G. | |
| dc.contributor.author | Spinella R. | |
| dc.contributor.author | La Torre F. | |
| dc.contributor.author | Tombetti E. | |
| dc.contributor.author | Amin R.H. | |
| dc.contributor.author | Mauro A. | |
| dc.contributor.author | Karamanakos A. | |
| dc.contributor.author | Carreño E. | |
| dc.contributor.author | Fonollosa A. | |
| dc.contributor.author | Cattalini M. | |
| dc.contributor.author | Breda L. | |
| dc.contributor.author | de-la-Torre A. | |
| dc.contributor.author | Wiesik-Szewczyk E. | |
| dc.contributor.author | Cifuentes-González C. | |
| dc.contributor.author | Ozen S. | |
| dc.contributor.author | Mazzei M.A. | |
| dc.contributor.author | Tosi G.M. | |
| dc.contributor.author | Frediani B. | |
| dc.contributor.author | Balistreri A. | |
| dc.contributor.author | Batu E.D. | |
| dc.contributor.author | Gupta V. | |
| dc.contributor.author | Cantarini L. | |
| dc.contributor.author | Fabiani C. | |
| dc.date.accessioned | 2024-07-22T08:01:55Z | |
| dc.date.available | 2024-07-22T08:01:55Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Purpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown. Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time. Results: Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99). Conclusions: Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features. © 2024 Taylor & Francis Group, LLC. | |
| dc.identifier.DOI-ID | 10.1080/09273948.2024.2346815 | |
| dc.identifier.issn | 09273948 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11652 | |
| dc.language.iso | English | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.title | Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders | |
| dc.type | Article |