Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children

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dc.contributor.authorŞen S.
dc.contributor.authorKızılay D.Ö.
dc.contributor.authorTaneli F.
dc.contributor.authorÖzen Ç.
dc.contributor.authorErtan P.
dc.contributor.authorÖzunan İ.
dc.contributor.authorYıldız R.
dc.contributor.authorErsoy B.
dc.date.accessioned2024-07-22T08:06:24Z
dc.date.available2024-07-22T08:06:24Z
dc.date.issued2021
dc.description.abstractObjective: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes. Methods: Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a non-diabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated. Results: Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018). Conclusion: Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes. © 2021 by Turkish Pediatric Endocrinology and Diabetes Society.
dc.identifier.DOI-ID10.4274/JCRPE.GALENOS.2021.2021.0020
dc.identifier.issn13085727
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13499
dc.language.isoEnglish
dc.publisherGalenos Publishing House
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdolescent
dc.subjectBiomarkers
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHepatitis A Virus Cellular Receptor 1
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectKidney Diseases
dc.subjectLipocalin-2
dc.subjectMale
dc.subjectPediatric Obesity
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectcreatinine
dc.subjectcystatin C
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjecthepatitis A virus cellular receptor 1
dc.subjectinsulin
dc.subjectlow density lipoprotein cholesterol
dc.subjectneutrophil gelatinase associated lipocalin
dc.subjecttestosterone
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjecttriacylglycerol
dc.subjectbiological marker
dc.subjectHAVCR1 protein, human
dc.subjecthepatitis A virus cellular receptor 1
dc.subjectLCN2 protein, human
dc.subjectneutrophil gelatinase associated lipocalin
dc.subjectadolescent
dc.subjectadult
dc.subjectanthropometry
dc.subjectArticle
dc.subjectblood pressure monitoring
dc.subjectbody mass
dc.subjectcase control study
dc.subjectchild
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectcross-sectional study
dc.subjectdiabetes mellitus
dc.subjectdiastolic blood pressure
dc.subjectdiet supplementation
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfree thyroxine index
dc.subjectglucose blood level
dc.subjecthomeostasis model assessment
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectkidney function
dc.subjectkidney injury
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicroalbuminuria
dc.subjectneutrophilia
dc.subjectobesity
dc.subjectoutpatient department
dc.subjectprevalence
dc.subjectprotein expression
dc.subjectquestionnaire
dc.subjectrisk factor
dc.subjecturinary tract infection
dc.subjecturine level
dc.subjectchildhood obesity
dc.subjectinsulin resistance
dc.subjectkidney disease
dc.subjectmetabolism
dc.subjectphysiology
dc.subjecturine
dc.titleUrinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
dc.typeArticle

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