Genetic findings of obsessive-compulsive disorder; [Obsesif-kompulsif bozuklukta genetik çalişmalar]

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dc.contributor.authorDemet M.M.
dc.date.accessioned2024-07-22T08:24:05Z
dc.date.available2024-07-22T08:24:05Z
dc.date.issued2005
dc.description.abstractObsessive-compulsive disorder (OCD) is characterized by repetitive, intrusive ideations, image or urges (obsession] and/or rigid, ritualistic and time-consuming behaviours (compulsions). Early evidences on inheritance of OCD have been obtained from family and twin studies. Segregation analysis provides basic support for existence of a major gene locus. In only published linkage analysis, it was reported that multipoint linkage was found on chromosome 9p. Recently, genetic studies have centered on plausible candidate genes, which are thought to be involved in the etiology of OCD. Preliminary findings from the studies of several candidate genes have contributed to previous clinical findings, especially related to serotonergic and dopaminergic systems. Also, the candidate genes of opioid, glutamatergic systems as well as the genes of immune system and neurodevelopmental progress give hope to researchers for future investigation of these systems. In this review, the family, twin, segregation, linkage, and candidate genes studies of OCD will be reviewed.
dc.identifier.issn10177833
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19822
dc.language.isoTurkish
dc.subjectglutamic acid
dc.subjectopiate
dc.subjectchromosome 9p
dc.subjectdopaminergic system
dc.subjectgene locus
dc.subjectgene segregation
dc.subjectgenetic linkage
dc.subjecthuman
dc.subjectimmune system
dc.subjectinheritance
dc.subjectnerve cell differentiation
dc.subjectobsessive compulsive disorder
dc.subjectreview
dc.subjectserotoninergic system
dc.titleGenetic findings of obsessive-compulsive disorder; [Obsesif-kompulsif bozuklukta genetik çalişmalar]
dc.typeReview

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