The role of resveratrol on full – Thickness uterine wound healing in rats

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dc.contributor.authorSayin O.
dc.contributor.authorMicili S.C.
dc.contributor.authorGoker A.
dc.contributor.authorKamaci G.
dc.contributor.authorErgur B.U.
dc.contributor.authorYilmaz O.
dc.contributor.authorGuner Akdogan G.
dc.date.accessioned2024-07-22T08:10:24Z
dc.date.available2024-07-22T08:10:24Z
dc.date.issued2017
dc.description.abstractObjective Healing of the uterus after cesarean section and myomectomy operation is clinically important. In this study, we aimed to investigate the effects of resveratrol (3,5,4′-o-trihydroxystilbene) on the wound healing process of the uterus in rats treated with resveratrol following full thickness injury of the uterus. Materials and methods Twenty-one female wistar albino rats were divided randomly into three groups (1) control group with no intervention (2) injury group with uterine full thickness injury (3) resveratrol group with uterine full thickness injury and treated with resveratrol. Resveratrol was injected by oral gavage at the doses of 0.5 mg/kg/day for 30 days following uterine full thickness injury. Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) distributions were assessed using the immunohistochemical methods in tissue and ELISA methods in the tissue homogenate. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were evaluated with colorimetric method and malondialdehyde (MDA) levels also were measured using high performance liquid chromatography in the tissue homogenate. The effects of resveratrol on the uterine histology also were evaluated histologically with the light microscopy. Results Histological evaluation and immunohistochemical evaluations showed that treatment with a resveratrol significantly increased the thickness of the uterine wall and VEGF expression and decreased expression PDGF during wound healing. Biochemically, GPx and SOD activities were increased significantly after treatment with resveratrol. Additionally, resveratrol administration decreased MDA levels. Conclusion These results showed that the antioxidant effects of resveratrol has been shown to have a positive influence on wound healing of the uterus. © 2017
dc.identifier.DOI-ID10.1016/j.tjog.2017.08.015
dc.identifier.issn10284559
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15224
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectFemale
dc.subjectGlutathione Peroxidase
dc.subjectMalondialdehyde
dc.subjectPlatelet-Derived Growth Factor
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStilbenes
dc.subjectSuperoxide Dismutase
dc.subjectTreatment Outcome
dc.subjectUterus
dc.subjectVascular Endothelial Growth Factor A
dc.subjectWound Healing
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectplatelet derived growth factor
dc.subjectresveratrol
dc.subjectsuperoxide dismutase
dc.subjectvasculotropin
dc.subjectantioxidant
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectplatelet derived growth factor
dc.subjectresveratrol
dc.subjectstilbene derivative
dc.subjectsuperoxide dismutase
dc.subjectvasculotropin A
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectcesarean section
dc.subjectcolorimetry
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectenzyme activity
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthigh performance liquid chromatography
dc.subjecthistology
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmyomectomy
dc.subjectmyometrium
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectrat
dc.subjecttissue homogenate
dc.subjectuterus
dc.subjectwound healing
dc.subjectanimal
dc.subjectdrug effect
dc.subjectinjuries
dc.subjectmetabolism
dc.subjectpathology
dc.subjecttreatment outcome
dc.subjectuterus
dc.subjectWistar rat
dc.subjectwound healing
dc.titleThe role of resveratrol on full – Thickness uterine wound healing in rats
dc.typeArticle

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