Tungsten disulfide nanoparticle-containing PCL and PLGA-coated bioactive glass composite scaffolds for bone tissue engineering applications

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dc.contributor.authorEnsoylu M.
dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:05:30Z
dc.date.available2024-07-22T08:05:30Z
dc.date.issued2021
dc.description.abstractIn the study, tungsten disulfide (WS2) nanoparticle-containing polymer-coated bioactive glass composite scaffolds were prepared for bone tissue engineering applications. Poly-ε-caprolactone (PCL) and poly(D,L-lactide-co-glycolide) (PLGA) were applied on the surface of the bioactive glass scaffolds fabricated by the polymer foam replication method. Results revealed that the presence of WS2 nanoparticles (0.1 to 2 wt%) embedded in polymer matrix improved the compression strength of the prepared scaffolds and their in vitro bioactivity in simulated body fluid. Composite scaffolds did not demonstrate a cytotoxic effect on pre-osteoblastic MC3T3-E1 cells after incubation for 72 h. SEM analysis showed that cells attached to the surface of the scaffolds and spread through the interconnected porous network. Gentamicin-loaded scaffolds demonstrated a controlled drug release behavior depending on the type of polymer applied on the coating layer. The presence of WS2 nanoparticles enhanced the drug release behavior of the scaffolds. It was concluded that bioactive glass-based composites fabricated in the study have the potential to be used for bone tissue engineering purposes. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10853-021-06494-w
dc.identifier.issn00222461
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13163
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectBody fluids
dc.subjectControlled drug delivery
dc.subjectNanoparticles
dc.subjectPlastic coatings
dc.subjectScaffolds
dc.subjectScaffolds (biology)
dc.subjectSulfur compounds
dc.subjectTargeted drug delivery
dc.subjectTissue
dc.subjectTungsten compounds
dc.subjectBone tissue engineering
dc.subjectComposite scaffolds
dc.subjectDrug-release behaviour
dc.subjectGlass composites
dc.subjectGlass scaffolds
dc.subjectGlycolide
dc.subjectL-lactide
dc.subjectPoly(ε caprolactone)
dc.subjectPolymer foams
dc.subjectTissue engineering applications
dc.subjectBioactive glass
dc.titleTungsten disulfide nanoparticle-containing PCL and PLGA-coated bioactive glass composite scaffolds for bone tissue engineering applications
dc.typeArticle

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