Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication

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dc.contributor.authorTopcu I.
dc.contributor.authorYentur E.A.
dc.contributor.authorKefi A.
dc.contributor.authorEkici N.Z.
dc.contributor.authorSakarya M.
dc.date.accessioned2024-07-22T08:24:02Z
dc.date.available2024-07-22T08:24:02Z
dc.date.issued2005
dc.description.abstractIsoniazid is an anti-tuberculosis drug, used commonly for treatment and prophylaxis of tuberculosis. Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma. Treatment requires admission to the intensive care unitfor ventilatory support, management of seizures and metabolic acidosis. Pyridoxine, in a dose equivalent to the amount of isoniazid ingested, is the only effective antidote. We report the successful treatment of two isoniazid intoxication cases: the case of a child developing an accidental acute isoniazid intoxication and an adult case of isoniazid intoxication with the intent of suicide.
dc.identifier.DOI-ID10.1177/0310057x0503300416
dc.identifier.issn0310057X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19777
dc.language.isoEnglish
dc.publisherAustralian Society of Anaesthetists
dc.rightsAll Open Access; Bronze Open Access
dc.subject4 aminobutyric acid
dc.subjectactivated carbon
dc.subjectanticonvulsive agent
dc.subjectbicarbonate
dc.subjectcharcoal
dc.subjectdiazepam
dc.subjectglutamate decarboxylase
dc.subjectisoniazid
dc.subjectpyridoxal 5 phosphate
dc.subjectpyridoxine
dc.subjectthiopental
dc.subjecttuberculostatic agent
dc.subjectacute disease
dc.subjectadult
dc.subjectanticonvulsant therapy
dc.subjectarticle
dc.subjectartificial ventilation
dc.subjectcase report
dc.subjectclinical feature
dc.subjectcoma
dc.subjectdiagnostic procedure
dc.subjectdose response
dc.subjectdrug blood level
dc.subjectdrug efficacy
dc.subjectdrug intoxication
dc.subjectfatality
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthuman
dc.subjectinfection prevention
dc.subjectintensive care
dc.subjectmetabolic acidosis
dc.subjectschool child
dc.subjectseizure
dc.subjectstomach lavage
dc.subjectsuicide
dc.subjecttreatment outcome
dc.subjecttuberculosis
dc.titleSeizures, metabolic acidosis and coma resulting from acute isoniazid intoxication
dc.typeArticle

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