European respiratory society clinical practice guidelines for the diagnosis of asthma in children aged

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dc.contributor.authorGaillard E.A.
dc.contributor.authorKuehni C.E.
dc.contributor.authorTurner S.
dc.contributor.authorGoutaki M.
dc.contributor.authorHolden K.A.
dc.contributor.authorde Jong C.C.M.
dc.contributor.authorLex C.
dc.contributor.authorLo D.K.H.
dc.contributor.authorLucas J.S.
dc.contributor.authorMidulla F.
dc.contributor.authorMozun R.
dc.contributor.authorPiacentini G.
dc.contributor.authorRigau D.
dc.contributor.authorRottier B.
dc.contributor.authorThomas M.
dc.contributor.authorTonia T.
dc.contributor.authorUsemann J.
dc.contributor.authorYilmaz O.
dc.contributor.authorZacharasiewicz A.
dc.contributor.authorMoeller A.
dc.date.accessioned2024-07-22T08:05:21Z
dc.date.available2024-07-22T08:05:21Z
dc.date.issued2021
dc.description.abstractDiagnosing asthma in children represents an important clinical challenge. There is no single gold standard test to confirm the diagnosis. Consequently, both over-, and under-diagnosis of asthma are frequent in children. A Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5 to 16 years using nine PICO (Population, Intervention, Comparator and Outcome) questions. The TF conducted systematic literature searches for all PICO questions and screened the outputs from these, including relevant full text articles. All TF members approved the final decision for inclusion of research papers. The TF assessed the quality of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. The TF then developed a diagnostic algorithm based on the critical appraisal of the PICO questions, preferences expressed by lay members and test availability. Proposed cut-offs were determined based on the best available evidence. The TF formulated recommendations using the GRADE Evidence to Decision framework. Based on the critical appraisal of the evidence and the Evidence to Decision Framework the TF recommends spirometry, bronchodilator reversibility testing and FeNO as first line diagnostic tests in children under investigation for asthma. The TF recommends against diagnosing asthma in children based on clinical history alone or following a single abnormal objective test. Finally, this guideline also proposes a set of research priorities to improve asthma diagnosis in children in the future. © 2021 European Respiratory Society. All rights reserved.
dc.identifier.DOI-ID10.1183/13993003.04173-2020
dc.identifier.issn09031936
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13089
dc.language.isoEnglish
dc.publisherEuropean Respiratory Society
dc.rightsAll Open Access; Bronze Open Access; Green Open Access
dc.subjectAsthma
dc.subjectBronchodilator Agents
dc.subjectChild
dc.subjectExhalation
dc.subjectHumans
dc.subjectNitric Oxide
dc.subjectSpirometry
dc.subjectbronchodilating agent
dc.subjecthistamine
dc.subjectmannitol
dc.subjectmethacholine
dc.subjectnitric oxide
dc.subjectadolescent
dc.subjectalgorithm
dc.subjectallergy test
dc.subjectArticle
dc.subjectasthma
dc.subjectchild
dc.subjectcomparative study
dc.subjectcoughing
dc.subjectdiagnostic test
dc.subjectdiagnostic test accuracy study
dc.subjectdyspnea
dc.subjectEuropean
dc.subjectevidence based practice
dc.subjectexercise
dc.subjectfractional exhaled nitric oxide
dc.subjectgold standard
dc.subjectGRADE approach
dc.subjecthealth care organization
dc.subjecthuman
dc.subjectintervention study
dc.subjectmedical history
dc.subjectmedical society
dc.subjectoutcome assessment
dc.subjectpeak expiratory flow
dc.subjectpractice guideline
dc.subjectresearch priority
dc.subjectsensitivity and specificity
dc.subjectspirometry
dc.subjectstudy design
dc.subjectsymptomatology
dc.subjectsystematic review
dc.subjectwheezing
dc.subjectexhalation
dc.titleEuropean respiratory society clinical practice guidelines for the diagnosis of asthma in children aged
dc.typeArticle

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