Treatment and prophylaxis with sucralfate ameliorates hypoxia/ reoxygenation-induced intestinal injury in pup rats

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dc.contributor.authorSencan A.B.
dc.contributor.authorSencan A.
dc.contributor.authorAktas S.
dc.contributor.authorHabif S.
dc.contributor.authorKabaroglu C.
dc.contributor.authorParildar Z.
dc.contributor.authorKaraca I.
dc.date.accessioned2024-07-22T08:24:07Z
dc.date.available2024-07-22T08:24:07Z
dc.date.issued2005
dc.description.abstractBackground: Sucralfate is widely used as a cytoprotective agent in patients with peptic ulcer and other intestinal mucosal injury. The aim of this study is to investigate whether sucralfate has any effect on the prevention and treatment of hypoxia/reoxygenation-induced intestinal injury. Material/Methods: Four groups of 10 1-day-old rat pups were studied. Hypoxia/reoxygenation (H/O)-induced intestinal injury was created. Group 1 was subjected to H/O just after birth and sacrificed at the end of the third day (Treatment Control). Group 2 was subjected to H/O just after birth and treated with sucralfate for 3 days. They were sacrificed at the end of the third day (Treatment). Group 3 was subjected to H/O on the third day after birth and then sacrificed (Prophylaxis Control). Group 4 was treated with sucralfate for the first 3 days, then H/O was created. Just after H/O, the pups were sacrificed (Prophylaxis). The intestinal tissues were harvested for histopathological investigation. Malondialdehyde (MDA) levels in the intestinal tissues were determined. Results: The mucosal injury grades of the treatment and prophylaxis groups were significantly lower than those of control groups (p<0.05). The mean MDA level in the treatment and prophylaxis groups were 0.42±0.17 and 0.21±0.23 nmol/mg respectively. The MDA levels of both groups were significantly lower than in the control groups (p<0.05). Conclusions: The present study shows that sucralfate has beneficial effects in an experimental model of hypoxia/reoxygenation-induced intestinal injury. © Med Sci Monit, 2005.
dc.identifier.issn12341010
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19843
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectAnoxia
dc.subjectAnti-Ulcer Agents
dc.subjectDisease Models, Animal
dc.subjectHumans
dc.subjectIntestinal Mucosa
dc.subjectIntestines
dc.subjectPeptic Ulcer
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSucralfate
dc.subjectmalonaldehyde
dc.subjectsucralfate
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjecthistopathology
dc.subjecthypoxia
dc.subjectintestine injury
dc.subjectintestine mucosa
dc.subjectnecrotizing enterocolitis
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectpeptic ulcer
dc.subjectprophylaxis
dc.subjectrat
dc.subjectreoxygenation
dc.titleTreatment and prophylaxis with sucralfate ameliorates hypoxia/ reoxygenation-induced intestinal injury in pup rats
dc.typeArticle

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