Evaluation and comparison of patients poisoned with acetaminophen and nonsteroidal anti-inflammatory drugs

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dc.contributor.authorÇelik A.
dc.contributor.authorŞaşmaz M.İ.
dc.date.accessioned2024-07-22T08:09:09Z
dc.date.available2024-07-22T08:09:09Z
dc.date.issued2019
dc.description.abstractWe aimed to determine and compare the clinical and demographical features, treatments, follow-up, poisoning scores and outcome of cases with the acetaminophen and NSAIDs intoxication. Data of the patients who were at the age of 18 and older and applied to the Emergency Department with the acetaminophen or NSAIDs intoxication were retrospectively examined. The cases were divided into 2 groups as the acetaminophen and NSAIDs group. The cases‟ age, gender, drug dose, hospitalization status and periods, poisoning scores (PSS, APACHE-II) and last conditions in discharging from the hospital were compared. The döşe was taken by 99 (55%) patients in the acetaminophen group was calculated as toxic, and intravenous acetylcysteine was administered to 70 (38.9%) patients as an antidote. When the APACHE-II scores of the patients hospitalized in the intensive care unit were examined, the mean APACHE-II score of 54 patients in the acetaminophen group was 3.15±3.70, the mean APACHE-II score of 34 patients in the NSAIDs group was 4.15±3.13 and it was statistically higher (p=0.031). All the patients followed-up in both groups were discharged with healing except only 1 (0.6%) patient who developed acute liver failure. Conclusion: The mean APACHE-II score was low in both groups. Therefore, following-up the patients in a unit such as a toxicology unit instead of the intensive care unit can be beneficial in terms of both reducing the place and labor force loads and cost. Moreover, the acetylcysteine treatments in the early period of the acetaminophen toxicity are very effective in decreasing the mortality and morbidity. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
dc.identifier.DOI-ID10.5505/ejm.2019.91259
dc.identifier.issn13010883
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14682
dc.language.isoEnglish
dc.publisherYuzuncu Yil Universitesi Tip Fakultesi
dc.rightsAll Open Access; Gold Open Access
dc.subjectacetylcysteine
dc.subjectactivated carbon
dc.subjectantidote
dc.subjectcodeine
dc.subjectdiclofenac
dc.subjectibuprofen
dc.subjectnonsteroid antiinflammatory agent
dc.subjectparacetamol
dc.subjectpseudoephedrine
dc.subjectabdominal pain
dc.subjectacute liver failure
dc.subjectadult
dc.subjectalcohol consumption
dc.subjectAPACHE
dc.subjectArticle
dc.subjectconfusion
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectdrug dose
dc.subjectdrug intoxication
dc.subjectexhaustion
dc.subjectfemale
dc.subjectheadache
dc.subjectheart palpitation
dc.subjecthospital discharge
dc.subjecthospitalization
dc.subjecthuman
dc.subjectintensive care unit
dc.subjectlength of stay
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnausea and vomiting
dc.subjectoutcome assessment
dc.subjectPoisoning Severity Score
dc.subjectretrospective study
dc.subjectscoring system
dc.subjectstomach lavage
dc.subjectweakness
dc.titleEvaluation and comparison of patients poisoned with acetaminophen and nonsteroidal anti-inflammatory drugs
dc.typeArticle

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