Molecular subtypes of invasive breast cancer: Correlation between PET/computed tomography and MRI findings

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dc.contributor.authorAkin M.
dc.contributor.authorOrguc S.
dc.contributor.authorAras F.
dc.contributor.authorKandiloglu A.R.
dc.date.accessioned2024-07-22T08:07:15Z
dc.date.available2024-07-22T08:07:15Z
dc.date.issued2020
dc.description.abstractObjective The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. Methods Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treatment PET/CT and MRI scans, and histopathological diagnosis at the authors' center were retrospectively reviewed. The relationship between FDG-PET/CT and MRI parameters, including maximum and mean standard uptake values (SUVmax and SUVmean, respectively), mean metabolic index (MImean) and metabolic tumor volume (MTV) values obtained from FDG-PET, and shape, margin, internal contrast-enhancement characteristics, kinetic curve types, functional tumor volume (FTV), apparent diffusion coefficient (ADC) values obtained from MRI was evaluated. Subsequently, differences among molecular subtypes (i.e. luminal A, luminal B, c-erbB-2 positive, and triple-negative) in terms of PET/CT and MRI parameters were evaluated. Results The luminal B subtype of invasive breast cancer had higher SUVmax and SUVmean (P = 0.002 and P = 0.017, respectively) values than the luminal A subtype. In addition, the triple-negative subtype had a higher SUVmax (P = 0.028) than the luminal A subtype. There was a statistically significant positive correlation between pathological tumor volume (PTV) and SUVmean (P = 0.019, r = 0.720). SUVmax and ADC were negatively correlated (P = 0.001; r =-0.384). A very strong positive correlation was detected between MTV and FTV (P = 0.000; r = 0.857), and between MTV and PTV (P = 0.006, r = 0.796), and between FTV and PTV (P = 0.006, r = 0.921). Conclusion Results of the present study suggest that SUVmax was superior to MRI findings in predicting molecular subtypes and that MRI was superior to PET/CT in predicting PTV. © 2020 Lippincott Williams and Wilkins. All rights reserved.
dc.identifier.DOI-ID10.1097/MNM.0000000000001220
dc.identifier.issn01433636
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13873
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectAdult
dc.subjectAged
dc.subjectBreast Neoplasms
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectPositron Emission Tomography Computed Tomography
dc.subjectRetrospective Studies
dc.subjectTumor Burden
dc.subjectfluorodeoxyglucose f 18
dc.subjectgadobenate dimeglumine
dc.subjectgadodiamide
dc.subjectgadoterate meglumine
dc.subjectadult
dc.subjectaged
dc.subjectapparent diffusion coefficient
dc.subjectArticle
dc.subjectbreast cancer
dc.subjectcontrast enhancement
dc.subjectdiagnostic value
dc.subjectdiffusion weighted imaging
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmaximum standardized uptake value
dc.subjectmean standardized uptake value
dc.subjectmetabolic tumor volume
dc.subjectnuclear magnetic resonance imaging
dc.subjectpositron emission tomography-computed tomography
dc.subjecttumor invasion
dc.subjectbreast tumor
dc.subjectdiagnostic imaging
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectretrospective study
dc.subjecttumor invasion
dc.subjecttumor volume
dc.titleMolecular subtypes of invasive breast cancer: Correlation between PET/computed tomography and MRI findings
dc.typeArticle

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