In vitro activity of ciprofloxacin, ofloxacin and levofloxacin against Myobacterium tuberculosis

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dc.contributor.authorAkcali S.
dc.contributor.authorSurucuoglu S.
dc.contributor.authorCicek C.
dc.contributor.authorOzbakkaloglu B.
dc.date.accessioned2024-07-22T08:24:07Z
dc.date.available2024-07-22T08:24:07Z
dc.date.issued2005
dc.description.abstractBackground: The increasing incidence of drug-resistant Mycobacterium tuberculosis necessitates therapeutic alternatives. The fluoroquinolones fulfill most of the criteria for an ideal class of antimycobacterial drugs. The aim of the present study was to determine to in vitro activities of ciprofloxacin, ofloxacin, and levofloxacin against M. tuberculosis strains. Methods: Susceptibility to four antituberculous drugs used in first-line treatment of tuberculosis was tested in 100 strains isolated from clinical samples. Nineteen strains (19%) were resistant to at least one of the four antituberculous drugs and 13 were multidrug resistant. The in vitro antimycobacterial activity of ciprofloxacin, ofloxacin, and levofloxacin was then determined against 100 M. tuberculosis strains using standard agar proportion dilution method. Results: Ciprofloxacin, ofloxacin, and levofloxacin were active against all tested strains of M. tuberculosis in vitro. Conclusions: Ciprofloxacin, ofloxacin, and levofloxacin have relatively potent in vitro activity against M. tuberculosis. Further in vivo studies are needed to determine the role of these compounds in the treatment of tuberculosis, but use should be limited to special circumstances rather than first-line treatment.
dc.identifier.DOI-ID10.5144/0256-4947.2005.409
dc.identifier.issn02564947
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19845
dc.language.isoEnglish
dc.publisherKing Faisal Specialist Hospital and Research Centre
dc.rightsAll Open Access; Green Open Access; Hybrid Gold Open Access
dc.subjectagar
dc.subjectantimycobacterial agent
dc.subjectciprofloxacin
dc.subjectethambutol
dc.subjectisoniazid
dc.subjectlevofloxacin
dc.subjectofloxacin
dc.subjectquinoline derived antiinfective agent
dc.subjectrifampicin
dc.subjectstreptomycin
dc.subjecttuberculostatic agent
dc.subjectantibacterial activity
dc.subjectarticle
dc.subjectbacterial strain
dc.subjectbacterium isolation
dc.subjectcontrolled study
dc.subjectdilution
dc.subjectdrug potency
dc.subjectdrug resistance
dc.subjectdrug sensitivity
dc.subjectin vitro study
dc.subjectmultidrug resistance
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectsampling
dc.subjectstandard
dc.subjecttuberculosis
dc.titleIn vitro activity of ciprofloxacin, ofloxacin and levofloxacin against Myobacterium tuberculosis
dc.typeArticle

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