The effect of cardiopulmonary bypass on the expression of inducible nitric oxide synthase, endothelial nitric oxide synthase, and vascular endothelial growth factor in the internal mammary artery

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dc.contributor.authorToprak V.
dc.contributor.authorŞirin B.H.
dc.contributor.authorTok D.
dc.contributor.authorÖzbilgin K.
dc.contributor.authorSaribülbül O.
dc.date.accessioned2024-07-22T08:23:34Z
dc.date.available2024-07-22T08:23:34Z
dc.date.issued2006
dc.description.abstractObjective: Endothelial function of a vessel may be impaired by local or systemic inflammation initiated by cardiopulmonary bypass (CPB) during coronary artery bypass graft (CABG) surgery. The present study was designed to investigate the early effects of CPB on nitric oxide production and vascular endothelial growth factor (VEGF) expression in internal mammary artery (IMA). Design: Prospective study. Setting: University hospital. Participants: Twenty patients who were scheduled for elective CABG with CPB. Interventions: IMA sections were studied immunohistochemically from these patients. The samples were taken from the distal end of the IMA before the institution of CPB and just before the construction of the IMA-left anterior descending artery anastomosis. Measurement and Main Results: After CPB, VEGF and endothelial nitric oxide synthase immunoreactivity increased significantly when compared with baseline values in the endothelium (p = 0.0156, p = 0.0313) and adventitia (p = 0.0313, p = 0.0001), respectively. No significant change was observed in inducible nitric oxide synthase immunoreactivity. Conclusions: The increase in eNOS expression may have been induced by the inflammation caused by CPB. © 2006 Elsevier Inc. All rights reserved.
dc.identifier.DOI-ID10.1053/j.jvca.2005.02.002
dc.identifier.issn10530770
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19575
dc.language.isoEnglish
dc.subjectCardiopulmonary Bypass
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMammary Arteries
dc.subjectNitric Oxide
dc.subjectNitric Oxide Synthase Type II
dc.subjectNitric Oxide Synthase Type III
dc.subjectProspective Studies
dc.subjectVascular Endothelial Growth Factor A
dc.subjectendothelial nitric oxide synthase
dc.subjectetomidate
dc.subjectfentanyl
dc.subjectinducible nitric oxide synthase
dc.subjectmidazolam
dc.subjectnitric oxide
dc.subjectpropofol
dc.subjectvasculotropin
dc.subjectvecuronium
dc.subjectadult
dc.subjectadventitia
dc.subjectaged
dc.subjectanesthesia induction
dc.subjectartery endothelium
dc.subjectarticle
dc.subjectcardiopulmonary bypass
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcoronary artery bypass graft
dc.subjectdemography
dc.subjectelective surgery
dc.subjectfemale
dc.subjectheart muscle ischemia
dc.subjectheart muscle revascularization
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectinternal mammary artery
dc.subjectleft anterior descending coronary artery
dc.subjectmale
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectprotein expression
dc.titleThe effect of cardiopulmonary bypass on the expression of inducible nitric oxide synthase, endothelial nitric oxide synthase, and vascular endothelial growth factor in the internal mammary artery
dc.typeArticle

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