Comparison of analgesic activity of the addition to neostigmine and fentanyl to bupivacaine in postoperative epidural analgesia

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dc.contributor.authorTekin S.
dc.contributor.authorTopcu I.
dc.contributor.authorEkici N.Z.
dc.contributor.authorCaglar H.
dc.contributor.authorErincler T.
dc.date.accessioned2024-07-22T08:23:21Z
dc.date.available2024-07-22T08:23:21Z
dc.date.issued2006
dc.description.abstractObjectives: To compare the analgesic and side effects of bupivacaine in combinations with neostigmine and fentanyl using patient-controlled-epidural analgesia (PCEA) methods in the postoperative period after abdominal hysterectomy. Methods: Seventy-five adult American Society of Anesthesiologists physical status I-II patients, aged 18-65 years were included in the study. The study took place in Celal Bayar University Hospital, Turkey between 2003-2004 years. After preoperative epidural catheterization, the patients were operated under general anesthesia. After surgery, the patients were randomly allocated in a double-blinded manner to receive PCEA and divided into 3 groups: Group B: 0.125% bupivacaine, Group N: 0.125% bupivacaine plus neostigmine 4 μg kg-1 and Group F: 0.125% bupivacaine plus 1 μg kg-1 fentanyl solutions (10 mL loading dose, 5 mL bolus dose, 10 min lockout time, 30 mL in 4 hour limit). During the following 24 hours, hemodynamic parameters, pain score using visual analog scale, total analgesic consumption, additional analgesic requirements, sedation, satisfaction, nausea scores and probable side-effects were evaluated. Results: Total analgesic consumption was 143.7 ± 7.2 mL in Group B, 123.4 ± 6.2 mL in Group N and 106 ± 8.3 mL in Groups F. The mean value in Group F was significantly lower than Group N and Group B (p<0.05), and was lower in Group N than Group B. Visual analog scale scores were lower in Group F than other groups (p<0.05). There were no differences in side effects between all groups. Conclusions: Fentanyl and neostigmine by the PCEA method can be used safely for postoperative analgesia after gynecologic surgery. They increase analgesia quality and satisfaction without an increase in side effects.
dc.identifier.issn03795284
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19490
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnalgesia, Epidural
dc.subjectAnalgesics
dc.subjectAnesthetics, Local
dc.subjectBupivacaine
dc.subjectCholinesterase Inhibitors
dc.subjectDouble-Blind Method
dc.subjectFemale
dc.subjectFentanyl
dc.subjectHumans
dc.subjectHysterectomy
dc.subjectMiddle Aged
dc.subjectNarcotics
dc.subjectNeostigmine
dc.subjectPain, Postoperative
dc.subjectbupivacaine
dc.subjectdiclofenac
dc.subjectfentanyl
dc.subjectneostigmine
dc.subjectnitrous oxide
dc.subjectoxygen
dc.subjectsevoflurane
dc.subjectthiopental
dc.subjectvecuronium
dc.subjectanalgesic agent
dc.subjectbupivacaine
dc.subjectcholinesterase inhibitor
dc.subjectfentanyl
dc.subjectlocal anesthetic agent
dc.subjectnarcotic agent
dc.subjectneostigmine
dc.subjectabdominal hysterectomy
dc.subjectadult
dc.subjectaged
dc.subjectanalgesic activity
dc.subjectanesthesist
dc.subjectarticle
dc.subjectbolus injection
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdouble blind procedure
dc.subjectdrug efficacy
dc.subjectdrug safety
dc.subjectepidural anesthesia
dc.subjectgeneral anesthesia
dc.subjecthallucination
dc.subjecthemodynamic parameters
dc.subjecthuman
dc.subjecthypotension
dc.subjectloading drug dose
dc.subjectmajor clinical study
dc.subjectnausea
dc.subjectpain assessment
dc.subjectpatient controlled analgesia
dc.subjectpatient satisfaction
dc.subjectpostoperative analgesia
dc.subjectpostoperative pain
dc.subjectpostoperative period
dc.subjectpractice guideline
dc.subjectpruritus
dc.subjectrandomized controlled trial
dc.subjectsedation
dc.subjectTurkey (republic)
dc.subjectuniversity hospital
dc.subjectuterus disease
dc.subjectvisual analog scale
dc.subjectvomiting
dc.subjectadolescent
dc.subjectfemale
dc.subjecthysterectomy
dc.subjectmiddle aged
dc.subjectpostoperative pain
dc.titleComparison of analgesic activity of the addition to neostigmine and fentanyl to bupivacaine in postoperative epidural analgesia
dc.typeArticle

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