Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study

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dc.contributor.authorAkpinar S.
dc.contributor.authorTekgunduz E.
dc.contributor.authorEsen R.
dc.contributor.authorYilmaz M.
dc.contributor.authorKarakus V.
dc.contributor.authorVural F.
dc.contributor.authorGediz F.
dc.contributor.authorAydogdu I.
dc.contributor.authorKaynar L.
dc.contributor.authorGoker H.
dc.contributor.authorKelkitli E.
dc.contributor.authorAyyildiz O.
dc.contributor.authorDemirkan F.
dc.date.accessioned2024-07-22T08:04:41Z
dc.date.available2024-07-22T08:04:41Z
dc.date.issued2022
dc.description.abstractThrombotic microanjiopathy (TMA) is a pathological diagnosis characterized by abnormalities of small vessels leading to microvascular thrombosis of arterioles and capillaries. The current prospective, non-interventional, multicenter study aimed to define the distribution of different TMA forms in adult Turkish patients who were referred for therapeutic plasma exchange (TPE) for presumptive diagnosis of TMA. Patients with serum ADAMTS13 activity <5% were diagnosed as having acquired thrombotic thrombocytopenic purpura (aTTP). Patients presenting with ADAMTS13 activity 6–10 % / normal renal function and patients with ADAMTS13 activity >10 %, normal renal function and no secondary TMA were treated as unclassified TMA. The study included a total of 80 patients (women: 50; man: 30) with a median age of 48 (20−74). Detailed evaluation at 1 month after hospital admission revealed aTTP, secondary TMA, infection/complement-associated hemolytic uremic syndrome and unclassified TMA in 29 (36.2 %), 22 (27.5 %), 23 (28.8 %) and 6 (7.5 %) patients respectively. As subclassification of various TMAs will dictate specific therapy, proper diagnosis in a timely manner is of utmost clinical significance. © 2022
dc.identifier.DOI-ID10.1016/j.transci.2022.103365
dc.identifier.issn14730502
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12781
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPlasma Exchange
dc.subjectProspective Studies
dc.subjectRegistries
dc.subjectThrombotic Microangiopathies
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectvon Willebrand factor cleaving proteinase
dc.subjectacquired thrombotic thrombocytopenic purpura
dc.subjectadult
dc.subjectaged
dc.subjectcomplement associated hemolytic uremic syndrome
dc.subjectenzyme activity
dc.subjectfemale
dc.subjecthemolytic uremic syndrome
dc.subjecthospital admission
dc.subjecthuman
dc.subjectkidney function
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticenter study
dc.subjectplasma exchange
dc.subjectprospective study
dc.subjectReview
dc.subjectsecondary thrombotic microangiopathy
dc.subjectthrombotic microangiopathy
dc.subjectTurkish citizen
dc.subjectclinical trial
dc.subjectmiddle aged
dc.subjectplasma exchange
dc.subjectprocedures
dc.subjectregister
dc.subjectthrombotic thrombocytopenic purpura
dc.subjectturkey (bird)
dc.subjectyoung adult
dc.titleProspective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study
dc.typeReview

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