Evaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study

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dc.contributor.authorAsçibasi K.
dc.contributor.authorÇökmüs F.P.
dc.contributor.authorDikici D.S.
dc.contributor.authorÖzkan H.M.
dc.contributor.authorAlçi D.
dc.contributor.authorAltunsoy N.
dc.contributor.authorKuru E.
dc.contributor.authorYüzeren S.
dc.contributor.authorAydemir Ö.
dc.date.accessioned2024-07-22T08:07:02Z
dc.date.available2024-07-22T08:07:02Z
dc.date.issued2020
dc.description.abstractPurpose/Background Emotional adverse effects due to antidepressant use may cause difficulties for the clinician in the treatment of depression. In this prospective study, the emotional adverse effects of antidepressants were evaluated in various aspects. Methods/Procedures Ninety eight patients diagnosed with major depressive disorder were included in the study. At 2nd, 4th, 8th, 12th, and 16th weeks, patients were assessed with Montgomery-Asberg Depression Rating Scale (MADRS), and the antidepressant dose was increased in patients with less than a 50% reduction at each visit compared with the initial MADRS score. The Oxford Questionnaire on the Emotional Side-effects of Antidepressants (OQESA) was used at the 8th-week and 16th-week visits. Findings/Results A significant difference is found in the OQESA score at the 8th-week visit compared with the 16th-week assessment (P < 0.001, t = 5.73). There were significant correlations between MADRS scores and OQESA scores both at the 8th (r = 0.346, P = 0.05) and the 16th (r = 0.490, P < 0.001) weeks. In regression analyses, at eighth-week assessment, MADRS score (B = 1.487, P = 0.002) and selective serotonin reuptake inhibitor use (B = 14.014, P = 0.023) had a significantly predicted OQESA score. Implications/Conclusions In this study, it is found that, as the rate of remitted patients is increased, OQESA scores get decreased, and furthermore, the OQESA score of the remitted group is statistically low when compared with that of the nonremitted group at the 8th- and 16th-week visits. Oxford Questionnaire on the Emotional Side-effects of Antidepressants and MADRS scores are significantly correlated in all assessments. These results suggest that the score obtained from OQESA may be related not only to the emotional adverse effects of antidepressants but also to the residual symptoms of depression. © Wolters Kluwer Health, Inc. All rights reserved.
dc.identifier.DOI-ID10.1097/JCP.0000000000001300
dc.identifier.issn02710749
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13783
dc.language.isoEnglish
dc.publisherLippincott Williams and Wilkins
dc.subjectAdult
dc.subjectAffective Symptoms
dc.subjectAntidepressive Agents
dc.subjectDepressive Disorder, Major
dc.subjectEmotions
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectRemission Induction
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectantidepressant agent
dc.subjectserotonin noradrenalin reuptake inhibitor
dc.subjectserotonin uptake inhibitor
dc.subjectvortioxetine
dc.subjectantidepressant agent
dc.subjectadult
dc.subjectArticle
dc.subjectcorrelation analysis
dc.subjectdisease duration
dc.subjectemotional disorder
dc.subjectfemale
dc.subjectfollow up
dc.subjecthospitalization
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmajor depression
dc.subjectmale
dc.subjectmental hospital
dc.subjectMontgomery Asberg Depression Rating Scale
dc.subjectOxford Questionnaire on the Emotional Side effects of Antidepressants
dc.subjectpriority journal
dc.subjectprivate practice
dc.subjectregression analysis
dc.subjectremission
dc.subjectside effect assessment
dc.subjecttreatment outcome
dc.subjectuniversity hospital
dc.subjectclinical trial
dc.subjectdrug effect
dc.subjectemotion
dc.subjectemotional disorder
dc.subjectmajor depression
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectprospective study
dc.subjectpsychology
dc.subjecttime factor
dc.subjectturkey (bird)
dc.subjectyoung adult
dc.titleEvaluation of Emotional Adverse Effects of Antidepressants: A Follow-up Study
dc.typeArticle

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