Clarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children

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dc.contributor.authorÇağan-Appak Y.
dc.contributor.authorGazi H.
dc.contributor.authorAyhan S.
dc.contributor.authorCengiz-Özyurt B.
dc.contributor.authorKurutepe S.
dc.contributor.authorKasırga E.
dc.date.accessioned2024-07-22T08:12:11Z
dc.date.available2024-07-22T08:12:11Z
dc.date.issued2016
dc.description.abstractThis study aims to evaluate Helicobacter pylori with clarithromycin resistant genotypes in Manisa region, Turkey. Two hundred patients, who received diagnosis of Helicobacter pylori infection histopathologically, were included. The sex, age and endoscopy indications of the patients were recorded. Polymerase chain reaction method was applied to determine the clarithromycin resistance rate and resistance genotypes at the histologic sections prepared from gastric biopsies that had been embedded in paraffin after fixation by formalin. Helicobacter pylori resistance to clarithromycin was found in 19/200 (9.5%) patients. 10/19 (52.6%) of these clarithromycin-resistant patients had A2143G mutation and 9/19 (47.4%) had A2142G mutation. A2142C mutation on 23S rRNA gene was not detected for any of the patients. Clarithromycin can be used as a first step treatment in the eradication of Helicobacter pylori for the children in our region; if the treatment fails for some patients, clarithromycin resistance, especially A2143G and A2142G mutations should be considered. © 2016, Turkish Journal of Pediatrics. All rights reserved.
dc.identifier.DOI-ID10.24953/turkjped.2016.04.004
dc.identifier.issn00414301
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15956
dc.language.isoEnglish
dc.publisherTurkish Journal of Pediatrics
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdolescent
dc.subjectAnti-Bacterial Agents
dc.subjectBiopsy
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectClarithromycin
dc.subjectDrug Resistance, Bacterial
dc.subjectFemale
dc.subjectGenotype
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectMale
dc.subjectPoint Mutation
dc.subjectPolymerase Chain Reaction
dc.subjectTurkey
dc.subjectclarithromycin
dc.subjectRNA 23S
dc.subjectantiinfective agent
dc.subjectclarithromycin
dc.subjectabdominal pain
dc.subjectadolescent
dc.subjectantibiotic resistance
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectDNA isolation
dc.subjectduodenum ulcer
dc.subjectdyspepsia
dc.subjectfemale
dc.subjectfollow up
dc.subjectgastritis
dc.subjectgastrointestinal endoscopy
dc.subjectgenotype
dc.subjectHelicobacter infection
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpeptic ulcer
dc.subjectpoint mutation
dc.subjectpolymerase chain reaction
dc.subjectantibiotic resistance
dc.subjectbiopsy
dc.subjectchild
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectpoint mutation
dc.subjectpreschool child
dc.subjectTurkey
dc.titleClarithromycin resistance and 23S rRNA gene point mutations of Helicobacter pylori infection in children
dc.typeArticle

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