Evaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome

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dc.contributor.authorBatum M.
dc.contributor.authorKısabay A.
dc.contributor.authorMayalı H.
dc.contributor.authorGöktalay T.
dc.contributor.authorKurt E.
dc.contributor.authorSelçuki D.
dc.contributor.authorYılmaz H.
dc.date.accessioned2024-07-22T08:07:08Z
dc.date.available2024-07-22T08:07:08Z
dc.date.issued2020
dc.description.abstractIntroduction: Hypoxia during sleep in obstructive sleep apnea syndrome (OSAS) increases intracranial pressure, decreases cerebral perfusion pressure, and alters vascular supply to the optic nerve. Pattern visual evoked potential (pVEP) has revealed that it causes alterations in the optic nerve, and optic coherence tomography has shown that it causes alterations in the retinal and macular layers. Objectives: To detect and compare possible alterations in macula and peripapillary retinal nerve fiber thickness (pRNFL) using OCT and in the optic nerve pathways using pVEP before and after positive airway pressure (PAP) in the patients with severe OSAS. Materials and methods: Thirty patients who were diagnosed as having severe OSAS in the neurology-sleep outpatient clinic and 30 healthy control subjects were included in the study. Ophthalmic examinations were performed prior to (month 0) and after (month 6) PAP treatment, and pVEP (peak time [PT] and amplitude) and OCT parameters (peripapillary retinal-macular layers) were compared. Results: In the comparison between the severe OSAS (before treatment) and control groups, thinning was found in pRNFL (average, nasal, inferior) and in the macular layers (external and internal superior quadrants) (p < 0.05). pVEP investigation revealed increased PT in P100 and N145 waves and decreased amplitude of N75–P100 waves. In the comparisons before and after PAP treatment, a decrease in PT of N75 and P100 waves and increase in N75–P100 amplitudes were found. In the pRNFL, significant thickening was found in the layers with thinning before treatment, whereas no significant thickening was found in macular layers, except for the fovea. Discussion: It was shown that PAP treatment in patients with severe OSAS prevents hypoxia without causing alterations in intraocular pressure and thus reduces inflammation and causes thickening in the pRNFL and macular layers. © 2020, Springer Nature B.V.
dc.identifier.DOI-ID10.1007/s10792-020-01426-0
dc.identifier.issn01655701
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13849
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media B.V.
dc.subjectEvoked Potentials, Visual
dc.subjectHumans
dc.subjectRetinal Ganglion Cells
dc.subjectSleep Apnea, Obstructive
dc.subjectTomography, Optical Coherence
dc.subjectVisual Pathways
dc.subjectadult
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontinuous positive airway pressure
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjecteye examination
dc.subjectfemale
dc.subjecthuman
dc.subjectmacula retinal nerve fiber layer thickness
dc.subjectmale
dc.subjectoptic nerve
dc.subjectoptical coherence tomography
dc.subjectoutpatient department
dc.subjectperipapillary retinal nerve fiber layer thickness
dc.subjectretina macula lutea
dc.subjectretinal nerve fiber layer thickness
dc.subjectsleep disordered breathing
dc.subjectvisual evoked potential
dc.subjectvisual system
dc.subjectoptical coherence tomography
dc.subjectretina ganglion cell
dc.subjectsleep disordered breathing
dc.subjectvisual system
dc.titleEvaluation of effects of positive airway pressure treatment on retinal fiber thickness and visual pathways using optic coherence tomography and visual evoked potentials in the patients with severe obstructive sleep apnea syndrome
dc.typeArticle

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