Changes in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal children

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dc.contributor.authorErsoy B.
dc.contributor.authorYücetürk A.V.
dc.contributor.authorTaneli F.
dc.contributor.authorÜrk V.
dc.contributor.authorUyanik B.S.
dc.date.accessioned2024-07-22T08:23:57Z
dc.date.available2024-07-22T08:23:57Z
dc.date.issued2005
dc.description.abstractObjective: Adenotonsillar hypertrophy (ATH) is associated with growth interruption during childhood. The aim of this study was to determine the changes in growth, body composition and biochemical markers associated with growth following adenotonsillectomy (A&T) in prepubertal children. Study design: Twenty-eight children aged 3-10 years (mean age 73.90 ± 20.97 months) with ATH were followed up for 1 year after A&T. During the same period of time, 20 healthy children of similar ages (mean age 73.7 ± 18.2 months) were followed up too. Methods: Height, weight as well as insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were measured during the preoperative period, 6 months and 1 year after surgery. Results: Height and weight of the patient group significantly increased during the first year after A&T (p < 0.01). Increase in height standard deviation score (SDS) during the first postoperative year reflected a true acceleration of growth (p = 0.04). Height and weight of patients were not significantly below those of their healthy peers at the preoperative measurement. Height velocity of the patients (p = 0.118), which was similar to that of their healthy peers in the first 6 months postoperatively, was significantly higher at the end of the second 6-month period after the operation (p = 0.048). IGF-1 levels of the patient group, which were significantly lower than those of the controls preoperatively (p < 0.001), increased to similar levels 1 year after the operation. IGFBP-3 levels of the patient group increased significantly after postoperative sixth month (p = 0.002). Conclusion: Although children with ATH do not have significant growth retardation, their growth rate is slower. Increase in weight and IGF-1 levels followed by the increase in height leads to an acceleration in growth rate after A&T. These results have led to the conclusion that either the levels or effect of growth hormone (GH) increase following A&T. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.ijporl.2005.02.020
dc.identifier.issn01655876
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19765
dc.language.isoEnglish
dc.subjectAdenoidectomy
dc.subjectAdenoids
dc.subjectAirway Obstruction
dc.subjectAnalysis of Variance
dc.subjectBiological Markers
dc.subjectBody Composition
dc.subjectBody Height
dc.subjectBody Weight
dc.subjectCase-Control Studies
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectGrowth
dc.subjectHumans
dc.subjectHypertrophy
dc.subjectInsulin-Like Growth Factor Binding Protein 3
dc.subjectInsulin-Like Growth Factor I
dc.subjectMale
dc.subjectRecurrence
dc.subjectTonsil
dc.subjectTonsillectomy
dc.subjectTonsillitis
dc.subjectTreatment Outcome
dc.subjectbiochemical marker
dc.subjectgrowth hormone
dc.subjectsomatomedin binding protein 3
dc.subjectsomatomedin C
dc.subjectadenotonsillectomy
dc.subjectarticle
dc.subjectbody composition
dc.subjectbody height
dc.subjectbody weight
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjectgrowth
dc.subjectgrowth acceleration
dc.subjectgrowth rate
dc.subjectgrowth retardation
dc.subjecthormone determination
dc.subjecthuman
dc.subjectmale
dc.subjectpostoperative period
dc.subjectpreoperative evaluation
dc.subjectpreoperative period
dc.subjectprepuberty
dc.subjectpriority journal
dc.subjecttonsil disease
dc.subjectvelocity
dc.titleChanges in growth pattern, body composition and biochemical markers of growth after adenotonsillectomy in prepubertal children
dc.typeArticle

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