Investigation of Dientamoeba fragilis Prevalence and Evaluation of Sociodemographic and Clinical Features in Patients with Gastrointestinal Symptoms

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dc.contributor.authorAykur M.
dc.contributor.authorCalıskan Kurt C.
dc.contributor.authorDirim Erdogan D.
dc.contributor.authorBiray Avcı C.
dc.contributor.authorVardar R.
dc.contributor.authorAydemir S.
dc.contributor.authorGirginkardeşler N.
dc.contributor.authorGündüz C.
dc.contributor.authorDagci H.
dc.date.accessioned2024-07-22T08:08:41Z
dc.date.available2024-07-22T08:08:41Z
dc.date.issued2019
dc.description.abstractBackground: Dientamoeba fragilis is a protozoan parasite of the human gastrointestinal tract and still controversial in association with gastrointestinal symptoms. Purpose: We present cross-sectional study of the prevalence of D. fragilis, and sociodemographic and clinical features in the patients with gastrointestinal symptoms. Methods: A total of 490 fecal specimens were collected from outpatients with gastrointestinal symptoms in the Department of Parasitology, Faculty of Medicine, Ege University and Celal Bayar University, Turkey. Fecal specimens were examined with microscopy and inoculated in Robinson medium. D. fragilis-positive samples were examined for the presence of other intestinal parasites using enzyme immunoassay. Real-time PCR analysis was performed on all samples. Results: Of the 490 stool specimens examined by real-time PCR, 59 patients were positive for D. fragilis infection with prevalence rate of 12.04%. Forty-four of positive patients (74.5%) were found to be infected with only D. fragilis, while 23.7% were co-infected with Blastocystis and 1.7% were co-infected with Rotavirus. No statistically significant difference was found in all the examined patients in terms of D. fragilis positivity for all sociodemographic parameters. Loose stool consistency was associated with the presence of D. fragilis, with 18.3% (P = 0.001). When the clinical symptoms of all the patients participating in this study were examined, diarrhea was statistically more significant in patients with the presence of D. fragilis (16.3%; P = 0.001). The rate of diarrhea in D. fragilis-positive patients (84.09%; P = 0.0005) was higher than that of D. fragilis-negative patients and it was statistically significant. Conclusion: This study is important for assessing the prevalence of D. fragilis and its association with other factors in symptomatic patients in a large sample group in Turkey, as well as investigating the relationship of identified symptoms with the D. fragilis pathogenicity. It is suggested that D. fragilis in this case is not a commensal parasite but a pathogenic parasite and that the most common clinical symptom is diarrhea. © 2019, Witold Stefański Institute of Parasitology, Polish Academy of Sciences.
dc.identifier.DOI-ID10.2478/s11686-018-00017-5
dc.identifier.issn12302821
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14480
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBlastocystis Infections
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCross-Sectional Studies
dc.subjectDientamoeba
dc.subjectDientamoebiasis
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFeces
dc.subjectFemale
dc.subjectGastrointestinal Diseases
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectMicroscopy
dc.subjectMiddle Aged
dc.subjectOutpatients
dc.subjectParasitology
dc.subjectPrevalence
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectRotavirus Infections
dc.subjectSocioeconomic Factors
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectblastocystosis
dc.subjectchild
dc.subjectcross-sectional study
dc.subjectDientamoeba
dc.subjectdientamoebiasis
dc.subjectenzyme linked immunosorbent assay
dc.subjectfeces
dc.subjectfemale
dc.subjectgastrointestinal disease
dc.subjecthuman
dc.subjectinfant
dc.subjectisolation and purification
dc.subjectmale
dc.subjectmicroscopy
dc.subjectmiddle aged
dc.subjectnewborn
dc.subjectoutpatient
dc.subjectparasitology
dc.subjectpathology
dc.subjectpreschool child
dc.subjectprevalence
dc.subjectprocedures
dc.subjectreal time polymerase chain reaction
dc.subjectRotavirus infection
dc.subjectsocioeconomics
dc.subjectturkey (bird)
dc.subjectvery elderly
dc.subjectyoung adult
dc.titleInvestigation of Dientamoeba fragilis Prevalence and Evaluation of Sociodemographic and Clinical Features in Patients with Gastrointestinal Symptoms
dc.typeArticle

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