Prediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy

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dc.contributor.authorPolat M.
dc.contributor.authorŞimşek A.
dc.contributor.authorTansuǧ N.
dc.contributor.authorSezer R.G.
dc.contributor.authorÖzkol M.
dc.contributor.authorBaşpinar P.
dc.contributor.authorTekgül H.
dc.date.accessioned2024-07-22T08:18:32Z
dc.date.available2024-07-22T08:18:32Z
dc.date.issued2013
dc.description.abstractBackground: Hypoxic ischemic encephalopathy may result in many neurological deficits. It is crucial to make early diagnosis and assess the prognosis correctly. Aims: We aimed to determine the factors to evaluate the prognosis of hypoxic ischemic encephalopathy. Methods: Electroencephalography, neuroimaging, periodic neurological exams and a developmental test at 44-48 months after discharge from the hospital were performed on twenty five term newborn infants with clinical evidence of hypoxic ischemic encephalopathy. Results: Normal/mildly abnormal neonatal electroencephalography correlated with favorable outcome, particularly if neuroimaging was normal. The cranial MRI sensitivity was 83.3%, while the specificity was 57.9%, the positive predictive value was 38.5%, and the negative predictive value was 91.6%. Moderate/severely abnormal electroencephalography and multifocal/diffuse cortical or deep gray matter lesions correlated with poor outcome. Conclusions: Newborn infants with hypoxic ischemic encephalopathy should be treated in neonatal intensive care units, assessed with periodic neurological examination, electroencephalogram and brain imaging. This would help to initiate early intervention and improve the outcome of patients. © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.ejpn.2012.11.004
dc.identifier.issn15322130
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17347
dc.language.isoEnglish
dc.subjectApgar Score
dc.subjectChild Development
dc.subjectChild, Preschool
dc.subjectElectroencephalography
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectHypoxia-Ischemia, Brain
dc.subjectInfant, Newborn
dc.subjectInfant, Newborn, Diseases
dc.subjectMale
dc.subjectPredictive Value of Tests
dc.subjectarticle
dc.subjectclinical article
dc.subjectelectroencephalography
dc.subjectfemale
dc.subjecthuman
dc.subjecthypoxic ischemic encephalopathy
dc.subjectinfant
dc.subjectmale
dc.subjectnerve cell differentiation
dc.subjectneuroimaging
dc.subjectneurologic examination
dc.subjectnewborn
dc.subjectnuclear magnetic resonance imaging
dc.subjectprediction
dc.subjectpredictive value
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectsensitivity and specificity
dc.titlePrediction of neurodevelopmental outcome in term neonates with hypoxic-ischemic encephalopathy
dc.typeArticle

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