The effect of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats
| dc.contributor.author | Kuscu, NK | |
| dc.contributor.author | Koyuncu, FM | |
| dc.contributor.author | Inan, S | |
| dc.contributor.author | Tuglu, I | |
| dc.contributor.author | Uyar, Y | |
| dc.contributor.author | Ozbilgin, K | |
| dc.date.accessioned | 2025-04-10T10:29:04Z | |
| dc.date.available | 2025-04-10T10:29:04Z | |
| dc.description.abstract | Objective: The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. Methods: Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiting for 4 weeks, they were randomized into three groups to receive either oral tibolone in two different doses or placebo. The treatment was continued for 5 weeks, and then the rats were sacrificed and the endometria were analyzed. Results: Low columnar epithelium of the endometrial surface, longer epithelium and stratified squamous epithelium were seen in the control low-dose and high-dose groups, respectively. The staining intensity of IGF-1 was mild in control, and moderate in both treatment groups, the difference between control the treatment groups was significant (P=0.015 for group L, and P=0.03 for group H). The staining intensity of IGFBP-1 was moderate in control, and strong in groups L and H. Again the difference was significant between control and both treatment groups (P=0.039 for grup L, and P=0.03 for group H). No significant difference was noted between each treatment group for both IGF-1 and IGFBP-1. Conclusion: Tibolone caused histological changes in endometrium and stimulated IGF-I and IGFBP-1 staining. Both low and high dose treatments led to moderate and strong staining intensities for IGF-1 and IGFBP-1, respectively. The strong staining intensity of IGFBP-1 is likely due to the progestagenic effect of tibolone. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | |
| dc.identifier.issn | 0378-5122 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/35852 | |
| dc.language.iso | English | |
| dc.title | The effect of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats | |
| dc.type | Article |