The effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey

Simple item page
dc.contributor.authorSaruç M.
dc.contributor.authorGoksel G.
dc.contributor.authorOzkaya S.
dc.contributor.authorGuclu F.
dc.contributor.authorOzbakkaloglu B.
dc.contributor.authorYuceyar H.
dc.date.accessioned2024-07-22T08:25:30Z
dc.date.available2024-07-22T08:25:30Z
dc.date.issued2001
dc.description.abstractIf cytotoxin-associated gene A (CagA) status affects the response rates of therapy, then it may be possible to predict Helicobacter pylori eradication rates. We aimed to evaluate the response to eradication treatment of H. pylori infection in CagA-positive and CagA-negative patients. A total of 184 patients (93 males, 91 females, mean age 42.6 ± 12.8 years) with H. pylori-positive chronic gastritis were studied. Subjects underwent a gastroscopy and biopsy specimens were taken from the gastric antrum, body, and fundus. Before the eradication therapy was given all patients were tested for CagA, TNF-α and gastrin levels. They were then prescribed lansoprazole (30 mg bid), clarithromycin (500 mg bid), and amoxicillin (1.0 mg bid) for one week. On the 8th week a second endoscopy was performed and further biopsy specimens were obtained from the same sites as in the initial endoscopy. One hundred and twenty-seven patients (69.1%) were found to be CagA positive and 57 patients (30.9%) were CagA negative. The total eradication rate was 82.6%. In the CagA-positive group this rate was 87.4%, and in the CagA-negative group it was 71.9% (P = 0.019). TNF-α levels were higher in the CagA-positive than in the CagA-negative group (P = 0.001). However, gastrin levels were not different between groups (P = 0.421). Our findings revealed that CagA-negative status might be a risk factor for failure of H. pylori triple therapies. The CagA pathogenicity island gives a growth advantage to H. pylori strains and has been associated with an increase in the inflammatory response at the gastric mucosal level. These properties could make CagA-positive H. pylori strains more susceptible to antibiotics.
dc.identifier.DOI-ID10.1590/S0100-879X2001001100010
dc.identifier.issn0100879X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20460
dc.language.isoEnglish
dc.publisherAssociacao Brasileira de Divulgacao Cientifica
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectBacteria (microorganisms)
dc.subjectHelicobacter
dc.subjectHelicobacter pylori
dc.subjectamoxicillin
dc.subjectantibiotic agent
dc.subjectCagA protein
dc.subjectclarithromycin
dc.subjectgastrin
dc.subjectlansoprazole
dc.subjecttumor necrosis factor alpha
dc.subjectadult
dc.subjectantibiotic sensitivity
dc.subjectarticle
dc.subjectbacterial gene
dc.subjectbacterial virulence
dc.subjectchronic gastritis
dc.subjectcontrolled study
dc.subjectdiagnostic value
dc.subjectdrug efficacy
dc.subjecteradication therapy
dc.subjectfemale
dc.subjectgastrin blood level
dc.subjectgastroscopy
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprediction
dc.subjectprotein determination
dc.subjectrisk factor
dc.subjectstatistical analysis
dc.subjectstomach antrum
dc.subjectstomach biopsy
dc.subjectstomach fundus
dc.subjectstomach mucosa
dc.subjectstrain difference
dc.subjecttreatment failure
dc.subjectTurkey (republic)
dc.titleThe effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey
dc.typeArticle

Files

Collections

Scopus Koleksiyonu