Associations between serum uric acid concentrations and cardiometabolic risk and renal injury in obese and overweight children

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dc.contributor.authorKızılay D.Ö.
dc.contributor.authorŞen S.
dc.contributor.authorErsoy B.
dc.date.accessioned2024-07-22T08:08:30Z
dc.date.available2024-07-22T08:08:30Z
dc.date.issued2019
dc.description.abstractObjective: The aim of this study was to assess the association between serum uric acid concentration (SUAC) and the parameters of the metabolic syndrome (MetS) and insulin resistance (IR). The secondary aim was to evaluate whether hyperuricemia is associated with renal injury and cardiovascular risk in obese (OB) and overweight (OW) children. Methods: The subjects of this study consisted of OB/OW children and adolescents (ages: 8-18 years). Sex and age specific serum uric acid (SUA) olarak degistirilecek percentiles were used and a SUA >75th percentile was accepted as hyperuricemia. Anthropometric data, blood pressure (BP) measurements and biochemical parameters, including fasting blood glucose, insulin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol, triglycerides (TG), aspartate aminotransferase, alanine aminotransferase, homeostatic model assessments of IR (HOMA-IR) and SUAC were recorded. Oral glucose tolerance tests (OGTT) were performed in all patients. MetS was defined according to the International Diabetes Federation criteria. Total cholesterol/HDL-c ratio >4 and TG/HDL-c ratio >2.2 were used as the atherogenic index (AI) indicating cardiovascular risk. Urinary albumin excretion in a 24-hour and also in a first-morning urine sample were measured. Renal injury was assessed by microalbuminuria according to the National Kidney Foundation criteria. Results: There were 128 participants; 52 (40%) had elevated (SUA >75th percentile) and 76 had (60%) normal SUAC. The mean±SD age was 13.1±2.6 years and 87 (67.4%) were female. The mean±SD weight was 73±18.97 kg and mean±SD height was 155.4±12.11 cm. There was no statistical difference between the groups with and without hyperuricemia in terms of age, sex, puberty stage and degree of obesity. Increased SUAC were significantly associated with higher waist-to-hip ratio (WHR), fasting insulin levels and insulin at 30 and 60 minutes during OGTT, HOMA-IR, lower HDL-c and presence of hypertriglyceridemia as well as with decreased HDL-c, increased AI, presence of IR and MetS. BP and microalbuminuria were not associated with SUAC. SUAC showed significant positive correlations with waist circumference, WHR, post-challenge glucose level at 60 minutes, with fasting insulin, post-challenge insulin levels at 30, 60, 90 and 120 minutes and also with HOMA-IR, total cholesterol/HDL-c ratio, TG/HDL-c ratio and a number of other criteria related to MetS. Also, an inverse correlation with HDL-c was noted. Conclusion: In OB/OW children frequency of MetS, IR and dislipidemia increases with increased SUAC, a finding independent of age, puberty, gender and body mass index. Patients meeting all of the MetS criteria had the highest SUAC. These results demonstrate that the association between UA and metabolic and cardiovascular risk factors can be detected early in childhood. Thus, we recommend monitoring SUAC in OB children and we believe that prevention of SUAC elevation in early life has a potential protective effect on metabolic impairment and subsequent comorbidities. © 2019 by Turkish Pediatric Endocrinology and Diabetes Society.
dc.identifier.DOI-ID10.4274/jcrpe.galenos.2018.2019.0241
dc.identifier.issn13085727
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14422
dc.language.isoEnglish
dc.publisherGalenos Yayincilik,
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdolescent
dc.subjectBiomarkers
dc.subjectBody Mass Index
dc.subjectCardiovascular Diseases
dc.subjectChild
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectHyperuricemia
dc.subjectKidney Diseases
dc.subjectMale
dc.subjectMetabolic Syndrome
dc.subjectObesity
dc.subjectOverweight
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectUric Acid
dc.subjectalanine aminotransferase
dc.subjectalbumin
dc.subjectaspartate aminotransferase
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectbiological marker
dc.subjecturic acid
dc.subjectadolescent
dc.subjectadult
dc.subjectanthropometric parameters
dc.subjectArticle
dc.subjectatherogenesis
dc.subjectbiochemical analysis
dc.subjectblood pressure measurement
dc.subjectcardiometabolic risk
dc.subjectchild
dc.subjectdiastolic blood pressure
dc.subjectdisease association
dc.subjectglucose blood level
dc.subjecthip circumference
dc.subjecthomeostasis model assessment
dc.subjecthuman
dc.subjecthypertriglyceridemia
dc.subjecthyperuricemia
dc.subjectinsulin blood level
dc.subjectinsulin resistance
dc.subjectkidney injury
dc.subjectmajor clinical study
dc.subjectmetabolic parameters
dc.subjectmetabolic syndrome X
dc.subjectmicroalbuminuria
dc.subjectmorbidity
dc.subjectnational health organization
dc.subjectobesity
dc.subjectoral glucose tolerance test
dc.subjectpuberty
dc.subjectschool child
dc.subjectsystolic blood pressure
dc.subjecturic acid blood level
dc.subjectwaist circumference
dc.subjectwaist hip ratio
dc.subjectblood
dc.subjectbody mass
dc.subjectcardiovascular disease
dc.subjectcomplication
dc.subjectfemale
dc.subjectfollow up
dc.subjecthyperuricemia
dc.subjectkidney disease
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectobesity
dc.subjectprognosis
dc.subjectretrospective study
dc.titleAssociations between serum uric acid concentrations and cardiometabolic risk and renal injury in obese and overweight children
dc.typeArticle

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