In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica

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dc.contributor.authorÖstan I.
dc.contributor.authorSaǧlam H.
dc.contributor.authorLimoncu M.E.
dc.contributor.authorErtabaklar H.
dc.contributor.authorToz S.Ö.
dc.contributor.authorÖzbel Y.
dc.contributor.authorÖzbilgin A.
dc.date.accessioned2024-07-22T08:22:45Z
dc.date.available2024-07-22T08:22:45Z
dc.date.issued2007
dc.description.abstractThis study aimed to evaluate the in vitro and in vivo leishmanicidal activity of an endemic Turkish plant and compare its efficacy with a reference drug. In addition to the in vitro activities of the ethanol, acidified and alkaloid extracts and furoquinoline alkaloids skimmianine and γ-fagarine, in vivo antileishmanial activitiy of the acidified extract of HaplophyUum myrtifolium Boiss. (Rutaceae) were investigated against Leishmania tropica (L. tropica), a causative agent of cutaneous leishmaniasis. All the extracts and pure compounds showed in vitro inhibitory activity against the promastigotes of. L tropica. The in vitro 50% inhibitory concentrations of γ-fagarine, acidified extract, ethanol extract, skimmianine and alkaloid extract against promastigotes were determined as 8.7,9.4,10.9,25.7 and 25.8 μ/ml respectively. In vivo results of HaplophyUum myrtifolium acidified extract showed that this plant has a limited effect on decreasing the lesion size of experimental mice infected with Leishmania tropica. To the best of our knowledge, this is the first time both the in vitro and in vivo antileishmanial activity of HaplophyUum mrytifolium have been reported in the same research.
dc.identifier.issn11217138
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19224
dc.language.isoEnglish
dc.subjectAdministration, Cutaneous
dc.subjectAlkaloids
dc.subjectAnimals
dc.subjectDrug Evaluation, Preclinical
dc.subjectEthanol
dc.subjectHumans
dc.subjectLeishmania
dc.subjectLeishmaniasis
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectPlant Extracts
dc.subjectQuinolines
dc.subjectRutaceae
dc.subjectTurkey
dc.subjectHaplophyllum
dc.subjectLeishmania tropica
dc.subjectMus
dc.subjectRutaceae
dc.subjectalcohol
dc.subjectalkaloid
dc.subjectgamma fagarine
dc.subjectgamma-fagarine
dc.subjectplant extract
dc.subjectquinoline derivative
dc.subjectskimmianine
dc.subjectunclassified drug
dc.subjectanimal
dc.subjectarticle
dc.subjectBagg albino mouse
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectgrowth, development and aging
dc.subjecthuman
dc.subjectintradermal drug administration
dc.subjectisolation and purification
dc.subjectLeishmania
dc.subjectleishmaniasis
dc.subjectmale
dc.subjectmouse
dc.subjectparasitology
dc.subjectRutaceae
dc.subjectTurkey (republic)
dc.titleIn vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica
dc.typeArticle

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