Tremor, Gait, and Balance Disorders in Essential Tremor and the Efficacy of Atenolol

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dc.contributor.authorKisabay A.K.A.
dc.contributor.authorDurmaz G.S.
dc.contributor.authorAtaç C.
dc.contributor.authorDuksal T.
dc.contributor.authorGökçay F.
dc.contributor.authorÇelebisoy N.
dc.date.accessioned2024-07-22T08:02:26Z
dc.date.available2024-07-22T08:02:26Z
dc.date.issued2023
dc.description.abstractBackground: To assess gait and balance in patients with essential tremor (ET), which is the most common tremor disorder characterized by bilateral action tremor of the hands with possible involvement of further tremor locations and to test the efficacy of atenolol on tremor and gait and balance. Methods: In this prospective study, gait and balance were evaluated by static posturography in addition to International Cooperative Ataxia Rating Scale (ICARS) in 22 ET patients without any additional neurologic signs on examination. Tremor severity was assessed by The Essential Tremor Rating Assessment Scale (TETRAS). The efficacy of atenolol 100 mg/day both on tremor and gait and balance was investigated. Posturographic recordings were performed in gender, age-, and height-matched healthy volunteers who constituted the control group. Results: The mean center of gravity sway velocity of the ET patients recorded on firm and foam surfaces with eyes open and closed was not significantly different from the healthy controls but sway velocity on tandem stance was significantly increased (P = 0.032). Gait speed (P = 0.015) was decreased and step width was increased (P = 0.001). An improvement in TETRAS scores was recorded with atenolol treatment (P = 0.046). An improvement not reaching statistical significance was present in ICARS scores (P = 0.059). However, posturographic parameters did not change significantly (P > 0.05). Conclusion: Increased sway velocity on tandem stance, decreased gait speed and increased step width are consistent with midline cerebellar dysfunction in ET patients with no obvious gait and balance deficits on clinical examination. Atenolol seems to be effective on tremor but does not cause a significant improvement in gait and balance deficits. © 2023 Neurological Sciences and Neurophysiology.
dc.identifier.DOI-ID10.4103/nsn.nsn_38_23
dc.identifier.issn2636865X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11865
dc.language.isoEnglish
dc.publisherWolters Kluwer Medknow Publications
dc.rightsAll Open Access; Gold Open Access
dc.subjectatenolol
dc.subjectceruloplasmin
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectataxia
dc.subjectbalance disorder
dc.subjectbiochemical analysis
dc.subjectceruloplasmin blood level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdemographics
dc.subjectdisease assessment
dc.subjectdrug dose increase
dc.subjectdrug efficacy
dc.subjectelectrocardiogram
dc.subjectessential tremor
dc.subjectEssential Tremor Rating Assessment Scale
dc.subjectfemale
dc.subjectgait
dc.subjectgravity
dc.subjecthuman
dc.subjectInternational Cooperative Ataxia Rating Scale
dc.subjectmale
dc.subjectmemory disorder
dc.subjectneurologic examination
dc.subjectnuclear magnetic resonance imaging
dc.subjectprospective study
dc.subjectspeech disorder
dc.subjectstabilography
dc.subjectstep width
dc.subjectthyroid function test
dc.subjectwalking speed
dc.titleTremor, Gait, and Balance Disorders in Essential Tremor and the Efficacy of Atenolol
dc.typeArticle

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