Evaluation of cardiac structure, exercise capacity and electrocardiography parameters in children with partial and complete growth hormone deficiency and their changes with short term growth hormone replacement therapy

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dc.contributor.authorAlkan F.
dc.contributor.authorErsoy B.
dc.contributor.authorKızılay D.O.
dc.contributor.authorOzyurt B.C.
dc.contributor.authorCoskun S.
dc.date.accessioned2024-07-22T08:03:02Z
dc.date.available2024-07-22T08:03:02Z
dc.date.issued2023
dc.description.abstractPurpose: To evaluate cardiac structure, exercise capacity and electrocardiography (ECG) parameters of children with complete and partial growth hormone (GH) deficiency (GHD) and the effect of 12 months GH treatment on these. Methods: M-mode echocardiography, ECG and exercise test expressed as metabolic equivalent (MET) were performed in children with GHD, aged 9–14 years, divided into those with a peak GH response < 7 µg/L (complete GHD; n = 30) and 7–10 µg/L (partial GHD; n = 17) after two GH stimulation tests, at baseline and 12 months after GH initiation. Forty-eight healthy peers underwent the same tests once. Results: Left ventricular mass (LVM) was significantly lower before treatment in both groups with GHD compared to healthy peers (p = 0.015 and p = 0.032) but LVM in the GHD groups was similar to controls after 12 months of treatment. The increase in LVM in the complete GHD group was significant (p = 0.044). LVM index was significantly reduced with treatment in children with partial GHD (p = 0.035). Max METs, VO2max and exercise duration were significantly increased in children with complete GHD after treatment (p = 0.022, p = 0.015 and p = 0.002, respectively). Significant changes in P wave and QTc dispersion on ECG between groups were within physiological limits. Conclusion: This study showed that children with both partial and complete GHD had smaller cardiac structures and less exercise capacity compared to their healthy peers prior to GH treatment but this improved with 12 months of treatment. The cardiac trophic effect of GH, as well as the effect of increasing exercise capacity, is greater in those with complete GHD than in those with partial GHD. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s11102-022-01295-z
dc.identifier.issn1386341X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12078
dc.language.isoEnglish
dc.publisherSpringer
dc.subjectChild
dc.subjectElectrocardiography
dc.subjectExercise Tolerance
dc.subjectGrowth Hormone
dc.subjectHormone Replacement Therapy
dc.subjectHuman Growth Hormone
dc.subjectHumans
dc.subjectHypopituitarism
dc.subjectInsulin-Like Growth Factor I
dc.subjectcreatinine
dc.subjectgrowth hormone
dc.subjecthemoglobin A1c
dc.subjectgrowth hormone
dc.subjecthuman growth hormone
dc.subjectsomatomedin C
dc.subjectadolescent
dc.subjectaerobic capacity
dc.subjectArticle
dc.subjectataxia
dc.subjectbody mass
dc.subjectchild
dc.subjectchildhood disease
dc.subjectclinical article
dc.subjectcongenital heart disease
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdiastolic blood pressure
dc.subjectdispersion
dc.subjectdizziness
dc.subjectDoppler echocardiography
dc.subjectechocardiography
dc.subjectelectrocardiogram
dc.subjectelectrocardiography
dc.subjectendothelial dysfunction
dc.subjectexercise
dc.subjectexercise test
dc.subjectfemale
dc.subjectgestational age
dc.subjectgrowth hormone deficiency
dc.subjectheart atrium conduction
dc.subjectheart left ventricle mass
dc.subjectheart rate
dc.subjecthormone response
dc.subjecthormone substitution
dc.subjecthuman
dc.subjecthypertension
dc.subjecthypotension
dc.subjecthypothyroidism
dc.subjecthypoxia
dc.subjectinsulin tolerance test
dc.subjectinterventricular septum
dc.subjectM mode echocardiography
dc.subjectmale
dc.subjectmetabolic equivalent
dc.subjectnuclear magnetic resonance imaging
dc.subjectoxygen consumption
dc.subjectP wave
dc.subjectperipheral arterial disease
dc.subjectQRS complex
dc.subjectQRS interval
dc.subjectQT interval
dc.subjectQTc interval
dc.subjectshort stature
dc.subjectsleep disordered breathing
dc.subjectsubstitution therapy
dc.subjectsystolic blood pressure
dc.subjectthorax pain
dc.subjecttissue Doppler imaging
dc.subjecttransthoracic echocardiography
dc.subjecttreadmill exercise
dc.subjectelectrocardiography
dc.subjectexercise tolerance
dc.subjecthormone substitution
dc.subjecthypopituitarism
dc.subjectmetabolism
dc.titleEvaluation of cardiac structure, exercise capacity and electrocardiography parameters in children with partial and complete growth hormone deficiency and their changes with short term growth hormone replacement therapy
dc.typeArticle

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