Prognostic value of initial antithrombin levels in neonatal sepsis

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dc.contributor.authorErsoy B.
dc.contributor.authorNehir H.
dc.contributor.authorAltinoz S.
dc.contributor.authorYilmaz O.
dc.contributor.authorDundar P.E.
dc.contributor.authorAydogan A.
dc.date.accessioned2024-07-22T08:22:46Z
dc.date.available2024-07-22T08:22:46Z
dc.date.issued2007
dc.description.abstractObjectives: We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. Methods: Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (aPTT) and liver function tests), these were correlated each other and with outcome of the babies. Results: Initial AT and fibrinogen levels were significantly lower in newborns with sepsis compared to control (P<0.05). Initial AT levels were lower in the ones who developed disseminated intravascular coagulation (DIC) compared to those without DIC (P <0.05). Initial AT levels were significantly lower in newborns who died as compared to survivors (P <0.05). Sensitivity of AT was highest at 15 mg/dL for prognosis in neonatal sepsis (sensitivity:92.3%, specificity:61.9%, positive predictive value : 61.9%, negative predictive value: 61.9%). Conclusion: Lower initial AT levels in neonatal sepsis are associated with a severe disease and increased mortality. It may be useful in predicting clinical outcome in neonatal sepsis.
dc.identifier.issn00196061
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19231
dc.language.isoEnglish
dc.subjectAntithrombins
dc.subjectFemale
dc.subjectFibrinogen
dc.subjectGram-Negative Bacterial Infections
dc.subjectGram-Positive Bacterial Infections
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectSepsis
dc.subjectantithrombin
dc.subjectfibrinogen
dc.subjectarticle
dc.subjectbacterium culture
dc.subjectblood analysis
dc.subjectcontrolled study
dc.subjectdiagnostic test
dc.subjectdisseminated intravascular clotting
dc.subjectear reconstruction
dc.subjectfibrinogen blood level
dc.subjecthuman
dc.subjectlaboratory test
dc.subjectliver function test
dc.subjectmajor clinical study
dc.subjectnewborn
dc.subjectnewborn sepsis
dc.subjectoutcome assessment
dc.subjectpartial thromboplastin time
dc.subjectprediction
dc.subjectprognosis
dc.subjectprotein blood level
dc.subjectprothrombin time
dc.subjectsensitivity and specificity
dc.subjectseptic shock
dc.subjectsepticemia
dc.subjectsurvival rate
dc.titlePrognostic value of initial antithrombin levels in neonatal sepsis
dc.typeArticle

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