Assessment of alveolar epithelial permeability with Tc-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome

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dc.contributor.authorPirildar T.
dc.contributor.authorGumuser G.
dc.contributor.authorRuksen E.
dc.contributor.authorSakar A.
dc.contributor.authorDinc G.
dc.contributor.authorSayit E.
dc.date.accessioned2024-07-22T08:21:00Z
dc.date.available2024-07-22T08:21:00Z
dc.date.issued2010
dc.description.abstractSjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands and usually presents as persistent dryness of the mouth and eyes. Lung disease in SjS has been reported to occur early following clinical presentation of the disease. In this study, technetium-99m diethylene triamine penta-acetic acid (Tc-99m DTPA) aerosol inhalation scintigraphy was used to assess the pulmonary membrane permeability in patients with primary SjS. A total of 18 patients with primary SjS and 13 healthy controls were investigated. Clinical evaluation, chest X-ray examination, pulmonary function tests, Tc-99m DTPA aerosol scintigraphy were performed in all the cases. The presence of respiratory symptoms (dyspnea and cough), duration of sicca symptoms were recorded. The clearance half time of Tc-99m DTPA radioaerosols in patients with SjS (20.49 ± 2.56 min) was faster when compared to normal controls (42.32 ± 13.28 min) (P = 0.000) which means that there is a significant increase in lung permeability in patients with SjS compared to the controls. There is also a significant difference between PI of patients with SjS (0.34 ± 0.09) and that of controls (0.42 ± 0.07) (P = 0.012). According to the results of our preliminary study, one can detect pulmonary involvement by Tc-99m DTPA aerosol inhalation scinti-graphy in patients with primary SjS. © Springer-Verlag 2009.
dc.identifier.DOI-ID10.1007/s00296-009-1023-3
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18411
dc.language.isoEnglish
dc.subjectAdministration, Inhalation
dc.subjectAdult
dc.subjectAerosols
dc.subjectCase-Control Studies
dc.subjectCell Membrane Permeability
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPilot Projects
dc.subjectPredictive Value of Tests
dc.subjectPulmonary Alveoli
dc.subjectRadiography, Thoracic
dc.subjectRadiopharmaceuticals
dc.subjectRespiratory Function Tests
dc.subjectRespiratory Mucosa
dc.subjectSjogren's Syndrome
dc.subjectTechnetium Tc 99m Pentetate
dc.subjectpentetate technetium tc 99m
dc.subjectadult
dc.subjectaerosol
dc.subjectaged
dc.subjectarticle
dc.subjectcell membrane permeability
dc.subjectclinical article
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectcoughing
dc.subjectdrug clearance
dc.subjectdrug half life
dc.subjectdyspnea
dc.subjectfemale
dc.subjecthuman
dc.subjectlung alveolus epithelium
dc.subjectlung disease
dc.subjectlung function test
dc.subjectlung scintiscanning
dc.subjectmale
dc.subjectpriority journal
dc.subjectSjoegren syndrome
dc.subjectthorax radiography
dc.subjectxerostomia
dc.titleAssessment of alveolar epithelial permeability with Tc-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome
dc.typeArticle

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