Serum levels of trace elements in patients with testicular cancers

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dc.contributor.authorKaba M.
dc.contributor.authorPirinççi N.
dc.contributor.authorYüksel M.B.
dc.contributor.authorGeçit I.
dc.contributor.authorGüneş M.
dc.contributor.authorDemir M.
dc.contributor.authorAkkoyun H.T.
dc.contributor.authorDemir H.
dc.date.accessioned2024-07-22T08:13:59Z
dc.date.available2024-07-22T08:13:59Z
dc.date.issued2015
dc.description.abstractIntroduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
dc.identifier.DOI-ID10.1590/S1677-5538.IBJU.2014.0460
dc.identifier.issn16775538
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16462
dc.language.isoEnglish
dc.publisherBrazilian Society of Urology
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBiomarkers, Tumor
dc.subjectCase-Control Studies
dc.subjectHumans
dc.subjectMale
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectReference Values
dc.subjectRisk Factors
dc.subjectSpectrophotometry, Atomic
dc.subjectStatistics, Nonparametric
dc.subjectTesticular Neoplasms
dc.subjectTrace Elements
dc.subjectYoung Adult
dc.subjecttrace element
dc.subjecttumor marker
dc.subjectadolescent
dc.subjectadult
dc.subjectatomic absorption spectrometry
dc.subjectblood
dc.subjectcase control study
dc.subjecthuman
dc.subjectmale
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectnonparametric test
dc.subjectpathology
dc.subjectreference value
dc.subjectrisk factor
dc.subjectTesticular Neoplasms
dc.subjectyoung adult
dc.titleSerum levels of trace elements in patients with testicular cancers
dc.typeArticle

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