Association between hematologic parameters and in-hospital mortality in patients with infective endocarditis

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dc.contributor.authorZencir C.
dc.contributor.authorAkpek M.
dc.contributor.authorSenol S.
dc.contributor.authorSelvi M.
dc.contributor.authorOnay S.
dc.contributor.authorCetin M.
dc.contributor.authorAkgullu C.
dc.contributor.authorElbi H.
dc.contributor.authorGungor H.
dc.date.accessioned2024-07-22T08:12:35Z
dc.date.available2024-07-22T08:12:35Z
dc.date.issued2015
dc.description.abstractEarly and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
dc.identifier.DOI-ID10.1016/j.kjms.2015.10.004
dc.identifier.issn1607551X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16115
dc.language.isoEnglish
dc.publisherElsevier (Singapore) Pte Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectBlood Platelets
dc.subjectEndocarditis
dc.subjectFemale
dc.subjectHospital Mortality
dc.subjectHumans
dc.subjectKaplan-Meier Estimate
dc.subjectLymphocyte Count
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectRegression Analysis
dc.subjectROC Curve
dc.subjectC reactive protein
dc.subjectprocalcitonin
dc.subjectadult
dc.subjectArticle
dc.subjectbacterial endocarditis
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectfemale
dc.subjectheart valve prosthesis
dc.subjecthematological parameters
dc.subjecthospital patient
dc.subjecthuman
dc.subjectlymphocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectpacemaker
dc.subjectplatelet lymphocyte ratio
dc.subjectpredictive value
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectblood
dc.subjectendocarditis
dc.subjecthospital mortality
dc.subjectKaplan Meier method
dc.subjectlymphocyte
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectmultivariate analysis
dc.subjectreceiver operating characteristic
dc.subjectregression analysis
dc.subjectthrombocyte
dc.titleAssociation between hematologic parameters and in-hospital mortality in patients with infective endocarditis
dc.typeArticle

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