MicroRNA dysregulation in manic and euthymic patients with bipolar disorder

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dc.contributor.authorCamkurt M.A.
dc.contributor.authorKarababa İ.F.
dc.contributor.authorErdal M.E.
dc.contributor.authorKandemir S.B.
dc.contributor.authorFries G.R.
dc.contributor.authorBayazıt H.
dc.contributor.authorAy M.E.
dc.contributor.authorKandemir H.
dc.contributor.authorAy Ö.I.
dc.contributor.authorCoşkun S.
dc.contributor.authorÇiçek E.
dc.contributor.authorSelek S.
dc.date.accessioned2024-07-22T08:07:47Z
dc.date.available2024-07-22T08:07:47Z
dc.date.issued2020
dc.description.abstractBackground: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3′- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. Subjects and Methods: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. Results: Four microRNAs (miR-29a-3p, p = 0.035; miR-106b-5p, p = 0.014; miR-107, p = 0.011; and miR-125a-3p, p = 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p = 0.032; miR-29a-3p, p = 0.001; miR-106a-5p, p = 0.034; miR-106b-5p, p = 0.003; miR-107, p < 0.001; miR-125a-3p, p = 0.016; and miR-125b-5p, p = 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p = 0.013, and miR-107, p = 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. Conclusions: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients. © 2019
dc.identifier.DOI-ID10.1016/j.jad.2019.09.060
dc.identifier.issn01650327
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14083
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectBipolar Disorder
dc.subjectCase-Control Studies
dc.subjectCyclothymic Disorder
dc.subjectFemale
dc.subjectGene Expression Regulation
dc.subjectGenetic Markers
dc.subjectHumans
dc.subjectMale
dc.subjectMicroRNAs
dc.subjectMiddle Aged
dc.subjectUp-Regulation
dc.subjectmicroRNA
dc.subjectmicroRNA 106b 5p
dc.subjectmicroRNA 107
dc.subjectmicroRNA 125a
dc.subjectmicroRNA 29a 3p
dc.subjectunclassified drug
dc.subjectbiological marker
dc.subjectmicroRNA
dc.subjectMIRN106 microRNA, human
dc.subjectMIRN107 microRNA, human
dc.subjectMIRN125 microRNA, human
dc.subjectMIRN29 microRNA, human
dc.subjectMIRN92 microRNA, human
dc.subjectadult
dc.subjectArticle
dc.subjectbipolar disorder
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjecteuthymia
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmania
dc.subjectmental health
dc.subjectpriority journal
dc.subjectstatistical analysis
dc.subjectupregulation
dc.subjectbipolar disorder
dc.subjectblood
dc.subjectcase control study
dc.subjectcyclothymia
dc.subjectgene expression regulation
dc.subjectgenetic marker
dc.subjectgenetics
dc.subjectmiddle aged
dc.titleMicroRNA dysregulation in manic and euthymic patients with bipolar disorder
dc.typeArticle

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