Indacaterol in chronic obstructive pulmonary disease: An update for clinicians
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2012
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Abstract
Bronchodilation is the cornerstone of chronic obstructive pulmonary disease (COPD) management and is based on regular treatment with one or more long-acting β2 agonists (LABAs). A novel bronchodilator, indacaterol, satisfies the requirements of an efficacious LABA: it has a relatively longer duration of action compared with existing LABAs and a fast onset of action. This review is a presentation of data on indacaterol with respect to its molecular characteristics as well as comparisons with other long-acting bronchodilators. Data from 12 relevant trials show that once-daily indacaterol provides significant, consistent and clinically important improvements in lung function (forced expiratory volume in 1 second), significant improvements in breathlessness and health status at least as good as or better than tiotropium, salmeterol and formoterol, and reduction in requirement for relief medication compared with tiotropium, salmeterol and formoterol. © 2012, SAGE Publications. All rights reserved.
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corticosteroid , fluticasone , formoterol , indacaterol , placebo , salbutamol , salmeterol , tiotropium bromide , binding affinity , bronchodilatation , bronchospasm , cardiovascular disease , cerebrovascular disease , chronic obstructive lung disease , clinical feature , coughing , disease exacerbation , dose response , drug absorption , drug dose comparison , drug dose increase , drug effect , drug efficacy , drug half life , drug mechanism , drug potency , drug safety , drug structure , drug tolerability , drug withdrawal , dyspnea , forced expiratory volume , glucose blood level , heart disease , heart infarction , human , infection , infestation , inspiratory capacity , lipophilicity , mediastinum disease , nonhuman , outcome assessment , patient compliance , potassium blood level , priority journal , QT prolongation , quality of life , respiratory tract disease , review , rhinopharyngitis , side effect , single drug dose , thorax disease , time to maximum plasma concentration , treatment duration