Association of fas -670a/g and fasl -843c/t gene polymorphisms on allograft nephropathy in pediatric renal transplant patients

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dc.contributor.authorErtan P.
dc.contributor.authorMir S.
dc.contributor.authorOzkayin N.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:21:12Z
dc.date.available2024-07-22T08:21:12Z
dc.date.issued2010
dc.description.abstractObjective: FAS and FASL polymorphisms are suggested to play an important role in tubulitis that is a major component of acute rejection. The aim of this study was to investigate the role of FAS-670A/G and FASL-843C/T gene polymorphisms on allograft nephropathy in pediatric renal transplant patients Methods: Fifty three patients (22 males 31 females) aged 2 to 20 years (mean 12.3±0.6) who had renal transplantation and fifty healthy control subjects (25 males 25 females) were enrolled in the study. Pearson's Chi Square test was used for the statistical analysis. Survival rates were estimated with the Kaplan Meier method. Age, sex, chronic renal failure etiology, treatment modality and duration and donor type were recorded. FAS-670A/G and FASL- 843C/T gene polymorphisms were compared between renal transplant patients and normal healthy population as well as between renal transplant patients with and without acute rejection. Findings: FAS-670A/G genotypes or alleles were not significantly different between control and transplant patients and among transplant patients with and without acute rejection (P>0.05 for all). FASL-843C/T genotypes and alleles were not different between transplantation and control groups (P>0.05 for all). However, FASL-843C/T alleles were significantly different between patients with and without AR (P=0.02). The percentages of Callele were higher in children with acute rejection (68.8% vs 44.6%). Conclusion: FASL gene polymorphisms may play a major role in acute rejection while FAS polymorphisms have not been found to be different between patients with and without acute renal graft rejection. © 2010 by Pediatrics Center of Excellence.
dc.identifier.issn10184406
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18506
dc.language.isoEnglish
dc.publisherBrieflands
dc.subjectalanine
dc.subjectcysteine
dc.subjectFas antigen
dc.subjectFas ligand
dc.subjectglycine
dc.subjectthreonine
dc.subjectadult
dc.subjectallele
dc.subjectarticle
dc.subjectchild
dc.subjectchronic allograft nephropathy
dc.subjectcontrolled study
dc.subjectDNA polymorphism
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectgenotype
dc.subjecthuman
dc.subjectkidney transplantation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpreschool child
dc.subjectpromoter region
dc.subjectsurvival rate
dc.titleAssociation of fas -670a/g and fasl -843c/t gene polymorphisms on allograft nephropathy in pediatric renal transplant patients
dc.typeArticle

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