Efficacy of azithromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey

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dc.contributor.authorDeǧerli K.
dc.contributor.authorKilimcioǧlu A.A.
dc.contributor.authorKurt Ö.
dc.contributor.authorTamay A.T.
dc.contributor.authorÖzbilgin A.
dc.date.accessioned2024-07-22T08:24:49Z
dc.date.available2024-07-22T08:24:49Z
dc.date.issued2003
dc.description.abstractA murine toxoplasmosis model with Balb/C mice was used to investigate the therapeutic and prophylactic efficacy of azithromycin in a native strain of Toxoplasma gondii. Initially, seven groups - four studies and three controls - were established and 103 tachyzoites of this native strain of T. gondii were injected intraperitoneally to the mice in groups 1, 2, 3, 4 and 7. Azithromycin was given to groups 1-4 at different times of infection orally between 100 and 300 mg/kg/day for 10 days. Azithromycin was found to be effective at 200 mg/kg/day and above in the prophylaxis, at 250 mg/kg/day and above in the treatment of toxoplasmosis. These results suggest that azithromycin is effective in the prophylaxis and early infection of a highly virulent strain of T. gondii, and it doubled the survival time in the late infection. Azithromycin could be an alternative treatment regimen for human toxoplasmosis, if supported by further clinical investigations. © 2003 Elsevier B.V. All rights reserved.
dc.identifier.DOI-ID10.1016/S0001-706X(03)00194-3
dc.identifier.issn0001706X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20148
dc.language.isoEnglish
dc.publisherElsevier
dc.subjectTurkey
dc.subjectMurinae
dc.subjectToxoplasma gondii
dc.subjectazithromycin
dc.subjectdisease control
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectinfection prevention
dc.subjectinjection
dc.subjectmale
dc.subjectmodel
dc.subjectmouse
dc.subjectmouse strain
dc.subjectnative species
dc.subjectnonhuman
dc.subjectsurvival time
dc.subjectToxoplasma gondii
dc.subjecttoxoplasmosis
dc.subjectTurkey (republic)
dc.titleEfficacy of azithromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey
dc.typeArticle

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