Serum procalcitonin and C-reactive protein kinetics as indicators of treatment outcome in hospitalized patients with community-acquired pneumonia

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dc.contributor.authorTaşbakan M.S.
dc.contributor.authorGündüz C.
dc.contributor.authorSayiner A.
dc.contributor.authorÇilli A.
dc.contributor.authorÇelenk Karaboğa B.
dc.contributor.authorŞakar Çoşkun A.
dc.contributor.authorDurmaz Yaman F.
dc.contributor.authorKilinç O.
dc.contributor.authorKiliç Soylar Ö.
dc.date.accessioned2024-07-22T08:12:21Z
dc.date.available2024-07-22T08:12:21Z
dc.date.issued2016
dc.description.abstractBackground/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients (57 males, mean age: 61.5 ± 16.7 years) were enrolled in the study. Treatment failure (TF) was observed in 20 patients (19.4%). Pneumonia Severity Index scores, serum CRP levels, and PCT levels on admission were significantly higher in the TF group. There were significant decreases in CRP and PCT levels between admission day and day 3 in the treatment success group. Conclusion: In patients with CAP, the body temperature and leukocyte count on admission do not predict outcome. Monitoring levels of CRP and PCT may be useful as a predictor of treatment outcome. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1507-20
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16024
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectBiomarkers
dc.subjectC-Reactive Protein
dc.subjectCalcitonin
dc.subjectCalcitonin Gene-Related Peptide
dc.subjectCommunity-Acquired Infections
dc.subjectFemale
dc.subjectHumans
dc.subjectKinetics
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProtein Precursors
dc.subjectC reactive protein
dc.subjectprocalcitonin
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectcalcitonin
dc.subjectcalcitonin gene related peptide
dc.subjectprotein precursor
dc.subjectadult
dc.subjectaged
dc.subjectantibiotic therapy
dc.subjectArticle
dc.subjectbody temperature
dc.subjectchemiluminescence immunoassay
dc.subjectcommunity acquired pneumonia
dc.subjectcontrolled study
dc.subjectempyema
dc.subjectfemale
dc.subjectfever
dc.subjectfollow up
dc.subjecthospital patient
dc.subjecthuman
dc.subjectinflammation
dc.subjectleukocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectpleura effusion
dc.subjectPneumonia Severity Index
dc.subjectsensitivity and specificity
dc.subjecttreatment failure
dc.subjecttreatment outcome
dc.subjectcommunity acquired infection
dc.subjectkinetics
dc.subjectprognosis
dc.titleSerum procalcitonin and C-reactive protein kinetics as indicators of treatment outcome in hospitalized patients with community-acquired pneumonia
dc.typeArticle

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