Intracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings

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dc.contributor.authorDuygulu G.
dc.contributor.authorOvali G.Y.
dc.contributor.authorÇalli C.
dc.contributor.authorKitis O.
dc.contributor.authorYünten N.
dc.contributor.authorAkalin T.
dc.contributor.authorIslekel S.
dc.date.accessioned2024-07-22T08:21:06Z
dc.date.available2024-07-22T08:21:06Z
dc.date.issued2010
dc.description.abstractObjective: We aimed to detect the frequency of restricted diffusion in intracerebral metastases and to find whether there is correlation between the primary tumor pathology and diffusion-weighted MR imaging (DWI) findings of these metastases. Material and methods: 87 patients with intracerebral metastases were examined with routine MR imaging and DWI. 11 hemorrhagic metastatic lesions were excluded. The routine MR imaging included three plans before and after contrast enhancement. The DWI was performed with spin-echo EPI sequence with three b values (0, 500 and 1000), and ADC maps were calculated. 76 patients with metastases were grouped according to primary tumor histology and the ratios of restricted diffusion were calculated according to these groups. ADCmin values were measured within the solid components of the tumors and the ratio of metastases with restricted diffusion to that which do not show restricted diffusion were calculated. Fisher's exact and Mann-Whitney U tests were used for the statistical analysis. Results: Restricted diffusion was observed in a total of 15 metastatic lesions (19, 7%). Primary malignancy was lung carcinoma in 10 of these cases (66, 6%) (5 small cell carcinoma, 5 non-small cell carcinoma), and breast carcinoma in three cases (20%). Colon carcinoma and testicular teratocarcinoma were the other two primary tumors in which restricted diffusion in metastasis was detected. There was no statistical significant difference between the primary pathology groups which showed restricted diffusion (p > 0.05). ADCmin values of solid components of the metastasis with restricted diffusion and other metastasis without restricted diffusion also showed no significant statistical difference (0.72 ± 0.16 × 10-3 mm2/s and 0.78 ± 21 × 10-3 mm2/s respectively) (p = 0.325). Conclusion: Detection of restricted diffusion on DWI in intracerebral metastasis is not rare, particularly if the primary tumor is lung or breast cancer. However we found that there is no correlation between the metastasis showing restricted diffusion and primary pathology. Prospective studies with larger groups and more information are necessary regarding the correlation between the primary tumor histopathology and the ADC values of metastasis with restricted diffusion. © 2009 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.ejrad.2009.03.004
dc.identifier.issn0720048X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18468
dc.language.isoEnglish
dc.subjectBrain Neoplasms
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectHumans
dc.subjectBiological organs
dc.subjectDiffusion
dc.subjectMagnetic resonance
dc.subjectMagnetic resonance imaging
dc.subjectMedical imaging
dc.subjectMulticarrier modulation
dc.subjectStatistical tests
dc.subjectTumors
dc.subjectB value
dc.subjectBefore and after
dc.subjectBreast Cancer
dc.subjectBreast carcinomas
dc.subjectCell carcinoma
dc.subjectColon carcinoma
dc.subjectContrast Enhancement
dc.subjectLung carcinoma
dc.subjectMann-Whitney U test
dc.subjectMetastatic lesions
dc.subjectMR imaging
dc.subjectProspective study
dc.subjectRestricted diffusion
dc.subjectSolid components
dc.subjectSpin echo
dc.subjectStatistical analysis
dc.subjectStatistical differences
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbrain metastasis
dc.subjectbreast carcinoma
dc.subjectcolon carcinoma
dc.subjectcontrast enhancement
dc.subjectdiffusion weighted imaging
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlung non small cell cancer
dc.subjectlung small cell cancer
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprimary tumor
dc.subjectpriority journal
dc.subjecttestis teratoma
dc.subjectPathology
dc.titleIntracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings
dc.typeArticle

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