Evaluation of prognostic factors in localized high-grade undifferentiated pleomorphic sarcoma: report of a multi-institutional experience of Anatolian Society of Medical Oncology

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dc.contributor.authorOzcelik M.
dc.contributor.authorSeker M.
dc.contributor.authorEraslan E.
dc.contributor.authorKoca S.
dc.contributor.authorYazilitas D.
dc.contributor.authorErcelep O.
dc.contributor.authorOzaslan E.
dc.contributor.authorKaya S.
dc.contributor.authorHacibekiroglu I.
dc.contributor.authorMenekse S.
dc.contributor.authorAksoy A.
dc.contributor.authorTaskoylu B.Y.
dc.contributor.authorVarol U.
dc.contributor.authorArpaci E.
dc.contributor.authorCiltas A.
dc.contributor.authorOksuzoglu B.
dc.contributor.authorZengin N.
dc.contributor.authorGumus M.
dc.contributor.authorAliustaoglu M.
dc.date.accessioned2024-07-22T08:12:12Z
dc.date.available2024-07-22T08:12:12Z
dc.date.issued2016
dc.description.abstractMost data on prognostic factors for patients with high-grade undifferentiated pleomorphic sarcoma (HGUPS) is obtained from analyses of soft tissue sarcomas. The purpose of this study was to evaluate the clinicopathologic features and their impact on outcomes specifically in patients diagnosed with HGUPS. In this multicenter trial, we retrospectively analyzed 112 patients who were diagnosed and treated at 12 different institutions in Turkey. We collected data concerning the patients, tumor characteristics, and treatment modalities. There were 69 males (61.6 %) and 43 females (38.4 %). Median age was 56 years (19–90). The most common anatomic site of tumor origin was the upper extremity. Pleomorphic variant was the predominant histological subtype. Median tumor size was 8.2 cm (0.6–30 cm). Tumors were mainly deeply seated (57.1 %). Fifty-seven patients (50.9 %) were stage II and the remainder were stage III at the time of diagnosis. Median follow-up was 30 months (2–160). The primary site of distant metastasis was the lung (73.5 %) and the second most common site was the liver (11.7 %). The 5-year overall survival, distant metastasis-free survival, and local recurrence-free survival rates were 56.3, 53.4, and 67.2 %, respectively. Multivariate analysis showed that Eastern Cooperative Oncology Group (ECOG) performance score of II (p = 0.033), deep tumor location (p = 0.000), and development of distant metastasis (p = 0.004) were negatively correlated with overall survival, and perioperative radiotherapy and negative microscopic margins were significant factors for local control rates (p = 0.000 for each). Deep tumor location (p = 0.003) was the only adverse factor related to distant metastasis-free survival. Deep tumor location, ECOG performance score of II, and development of distant metastasis carry a poor prognostic implication on overall survival. These will aid clinicians in predicting survival and treatment decision. © 2015, International Society of Oncology and BioMarkers (ISOBM).
dc.identifier.DOI-ID10.1007/s13277-015-4359-1
dc.identifier.issn10104283
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15960
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media B.V.
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectHumans
dc.subjectLiver Neoplasms
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Metastasis
dc.subjectNeoplasm Recurrence, Local
dc.subjectPrognosis
dc.subjectSarcoma
dc.subjectUpper Extremity
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer localization
dc.subjectcancer prognosis
dc.subjectcancer radiotherapy
dc.subjectcancer staging
dc.subjectclinical feature
dc.subjectdistant metastasis
dc.subjectdistant metastasis free survival
dc.subjectfemale
dc.subjectfollow up
dc.subjecthigh grade undifferentiated pleomorphic sarcoma
dc.subjecthuman
dc.subjectlocal recurrence free survival
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticenter study
dc.subjectoverall survival
dc.subjectperioperative period
dc.subjectpriority journal
dc.subjectsarcoma
dc.subjectsex ratio
dc.subjectsurvival time
dc.subjecttumor volume
dc.subjectdisease free survival
dc.subjectLiver Neoplasms
dc.subjectLung Neoplasms
dc.subjectmetastasis
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectprognosis
dc.subjectsarcoma
dc.subjectsecondary
dc.subjecttumor recurrence
dc.subjectupper limb
dc.subjectvery elderly
dc.titleEvaluation of prognostic factors in localized high-grade undifferentiated pleomorphic sarcoma: report of a multi-institutional experience of Anatolian Society of Medical Oncology
dc.typeArticle

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