Nail changes in connective tissue diseases: Do nail changes provide clues for the diagnosis?

Simple item page
dc.contributor.authorTunc S.E.
dc.contributor.authorErtam I.
dc.contributor.authorPirildar T.
dc.contributor.authorTurk T.
dc.contributor.authorOzturk M.
dc.contributor.authorDoganavsargil E.
dc.date.accessioned2024-07-22T08:22:55Z
dc.date.available2024-07-22T08:22:55Z
dc.date.issued2007
dc.description.abstractObjective: To evaluate the frequency and the specificity of nail changes associated with connective tissue diseases (CTD). Methods: In a case-control study, 190 patients including those with systemic lupus erythematosus (SLE; 56), rheumatoid arthritis (RA, 47), primary Sjögren's syndrome (pSS; 35), systemic sclerosis (SSc; 39), and dermatomyositis/polymyositis (DM/PM; 13) were enrolled in the study. Patients with SLE and other CTDs were compared with two different control groups. Twenty nails were examined. Nail features were noted and classified. Nail samples were collected for mycological cultures. Results: In patients with SLE, erythema of proximal nailfold (P < 0.01), splinter haemorrhages in fingernails (P < 0.01), capillary loops in proximal nailfold (P < 0.05), periungual erythema (P < 0.05), and thin nail plates (P < 0.05) were more common than those in controls. Only splinter haemorrhages were associated with the disease activity. In patients with SSc and DM/PM, splinter haemorrhages (P < 0.05) and capillary loops in proximal nailfold (P < 0.01) in fingernails were common as well. Increase in longitudinal curvature (P < 0.001), transverse curvature (P < 0.01), and white dull colour in fingernails were other frequent findings in patients with SSc. Increase in transverse curvature was associated with the disease activity in SSc. In patients with RA, splinter haemorrhages (P < 0.05), red lunula (P < 0.05), and white dull colour (P < 0.05) in fingernails were frequent. The sensitivity values of all these changes were very low. However, their specificity values were found to be relatively high. Conclusion: Proximal nailfold is the most important site of affection in CTDs. These nail changes can be used in combination with highly sensitive diagnostic modalities to establish an accurate diagnosis. © 2007 The Authors Journal compilation © 2007 European Academy of Dermatology and Venereology.
dc.identifier.DOI-ID10.1111/j.1468-3083.2006.02012.x
dc.identifier.issn14683083
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19275
dc.language.isoEnglish
dc.subjectAdult
dc.subjectArthritis, Rheumatoid
dc.subjectCapillaries
dc.subjectCase-Control Studies
dc.subjectConnective Tissue Diseases
dc.subjectDermatomyositis
dc.subjectErythema
dc.subjectFemale
dc.subjectHemorrhage
dc.subjectHumans
dc.subjectKeratosis
dc.subjectLupus Erythematosus, Systemic
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNail Diseases
dc.subjectNails
dc.subjectOnychomycosis
dc.subjectPigmentation Disorders
dc.subjectPolymyositis
dc.subjectScleroderma, Systemic
dc.subjectSensitivity and Specificity
dc.subjectSjogren's Syndrome
dc.subjectadult
dc.subjectarticle
dc.subjectbleeding
dc.subjectcase control study
dc.subjectconnective tissue disease
dc.subjectcontrolled study
dc.subjectdermatomyositis
dc.subjectdisease activity
dc.subjectdisease association
dc.subjecterythema
dc.subjectfemale
dc.subjectfinger nail
dc.subjectfungus culture
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnail disease
dc.subjectpolymyositis
dc.subjectpriority journal
dc.subjectrheumatoid arthritis
dc.subjectsensitivity and specificity
dc.subjectSjoegren syndrome
dc.subjectsystemic lupus erythematosus
dc.subjectsystemic sclerosis
dc.titleNail changes in connective tissue diseases: Do nail changes provide clues for the diagnosis?
dc.typeArticle

Files

Collections

Scopus Koleksiyonu