Diagnostic modalities in premature rupture of membranes
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Date
2015
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Abstract
Objectives: Rupture of membranes prior to the onset of labor is known as Premature Rupture of Membranes (PROM). Early and correct diagnosis is crucial in order to prevent fetal and maternal risks that can be life threatening. We aimed to investigate the diagnostic ability of the tests in PROM. Materials and Methods: Nitrazine test, fern test, amnio-dye test, biochemical tests (insulin-like growth factor binding protein-1 and placental alpha microglobulin-1) were evaluated in terms of effectiveness in diagnosis of PROM. Results: A gold standard method has not yet been defined in PROM. Diagnostic tests (nitrazine test, fern test, Insulin-like Growth Factor Binding Protein-1 “IGFBP-1” and Placental Alpha Microglobulin-1 “PAMG-1”) should be used when the diagnosis is not certain following history, examination with sterile speculum and ultrasonography evaluation. Conclusion: IGFBP-1 and PAMG-1 are tests based on bedside immunochromatographic method. Especially, PAMG-1 comes into prominence with its high sensitivity and specificity. © 2015 The Author(s).
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alpha 1 microglobulin , chorionic gonadotropin beta subunit , creatinine , fibronectin , lactic acid , prolactin , somatomedin binding protein 1 , urea , amnio dye test , amnion fluid , Article , diagnostic test , echography , female , fern test , human , immunoaffinity chromatography , nitrazine test , predictive value , premature fetus membrane rupture , sensitivity and specificity , vaginal speculum