Serum IGF-1 levels correlate negatively to liver damage in diabetic rats

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dc.contributor.authorAksu I.
dc.contributor.authorBaykara B.
dc.contributor.authorKiray M.
dc.contributor.authorGurpinar T.
dc.contributor.authorSisman A.R.
dc.contributor.authorEkerbicer N.
dc.contributor.authorTas A.
dc.contributor.authorGokdemir-Yazar O.
dc.contributor.authorUysal N.
dc.date.accessioned2024-07-22T08:18:29Z
dc.date.available2024-07-22T08:18:29Z
dc.date.issued2013
dc.description.abstractDiabetes and insulin resistance frequently cause liver damage. Diabetes also causes reduction in liver and blood IGF-1 levels. We investigated the relation between liver damage and IGF-1 levels in diabetic rats. Fourteen Wistar albino rats were divided into control and diabetic groups. Diabetes was induced by streptozotocin. Rats were sacrificed for biochemical and histologic examinations 2 weeks after streptozotocin injection. Serum and liver IGF-1 levels were decreased, liver malondialdehyde (MDA) levels were increased, glutathione peroxidase (GPx) enzymes activities were decreased and serum alanine aminotransferase (ALT) levels were increased in diabetic group. Microscopic examination of liver revealed that normal tissue organization was disrupted in streptozotocin-induced diabetic rats. There was a strongly positive correlation between blood glucose levels and liver injury, and blood and liver IGF-1 levels. There was a strongly negative correlation between blood IGF-1 levels and hepatic injury. Our results suggest that reduction of blood IGF-1 levels correlates with hepatic injury and circulating IGF-1 levels may have predictive value for determining hepatic damage that results from diabetes. In addition, circulating IGF-1 levels are correlated with glutathione levels and the oxidative stress status of diabetic rat liver. © 2013 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2012.758311
dc.identifier.issn14737760
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17313
dc.language.isoEnglish
dc.subjectAlanine Transaminase
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectDiabetes Mellitus, Experimental
dc.subjectFemale
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectInsulin-Like Growth Factor I
dc.subjectLiver
dc.subjectMalondialdehyde
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRattus
dc.subjectalanine aminotransferase
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectsomatomedin C
dc.subjectanimal
dc.subjectarticle
dc.subjectblood
dc.subjectexperimental diabetes mellitus
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectliver
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectrat
dc.subjectWistar rat
dc.titleSerum IGF-1 levels correlate negatively to liver damage in diabetic rats
dc.typeArticle

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