Safety of psychotropic medications in pregnancy: An observational cohort study

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dc.contributor.authorÖztürk Z.
dc.contributor.authorOlmez E.
dc.contributor.authorGurpinar T.
dc.contributor.authorGok S.
dc.contributor.authorVural K.
dc.date.accessioned2024-07-22T08:12:18Z
dc.date.available2024-07-22T08:12:18Z
dc.date.issued2016
dc.description.abstractObjective: The question of harmfulness of the psychiatric drugs creates a major dilemma for pregnant women. The risks associated with prenatal psychotropic drug exposure are often overestimated. It is unclear that psychotropic medication or disorders themselves increase the risk of adverse pregnancy outcomes. The purpose of this study is to generate data about the safety of psychotropic drugs in pregnancy and maternal characteristics of the pregnant women exposed to these drugs. Method: An observational cohort study was performed. Pregnancy outcomes of 135 pregnancies after psychotropic drug exposure are compared to a control group of 275 pregnancies. Results: There were no statistically significant differences in rates of major malformations, miscarriages, and preterm deliveries between the two groups. However, the rate of elective abortions was higher in the exposed group compared to the control group (11.1% vs. 5.1%, respectively; RR 2.18; 95% CI: 1.09-4.39), and most of them were nulliparous (45.2%). The majority of the pregnant women did not smoke cigarettes and no alcohol consumption was reported in both groups. Conclusion: Our study showed that there was a tendency to terminate pregnancy among women exposed to psychotropic drugs. An accurate risk assessment about drug safety and informing pregnant women would help to prevent unnecessary terminations of pregnancies. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
dc.identifier.DOI-ID10.5455/bcp.20160207082039
dc.identifier.issn10177833
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15987
dc.language.isoEnglish
dc.publisherCukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali
dc.rightsAll Open Access; Bronze Open Access
dc.subjectalprazolam
dc.subjectcarbamazepine
dc.subjectescitalopram
dc.subjectfluoxetine
dc.subjecthydroxyzine
dc.subjectlamotrigine
dc.subjectmirtazapine
dc.subjectolanzapine
dc.subjectparoxetine
dc.subjectpsychotropic agent
dc.subjectquetiapine
dc.subjectsertraline
dc.subjectvalproic acid
dc.subjectvenlafaxine
dc.subjectArticle
dc.subjectcohort analysis
dc.subjectcongenital malformation
dc.subjectcontrolled study
dc.subjectdrug exposure
dc.subjectdrug safety
dc.subjectfemale
dc.subjectfetus death
dc.subjectfetus mortality
dc.subjecthuman
dc.subjectobservational study
dc.subjectpregnancy
dc.subjectpremature labor
dc.subjectradiation exposure
dc.subjectsmoking
dc.subjectspontaneous abortion
dc.titleSafety of psychotropic medications in pregnancy: An observational cohort study
dc.typeArticle

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