TGF-βs and SMADs activities at the site of failed neural tube in the human embryos

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dc.contributor.authorBarutcuoglu M.
dc.contributor.authorUmur A.S.
dc.contributor.authorVatansever H.S.
dc.contributor.authorUmur N.
dc.contributor.authorOzbilgin K.
dc.contributor.authorSayhan S.
dc.contributor.authorSelcuki M.
dc.date.accessioned2024-07-22T08:18:49Z
dc.date.available2024-07-22T08:18:49Z
dc.date.issued2013
dc.description.abstractAim: Transforming growth factor β (TGF-β) and Smads control intracellular signaling pathways in neurulation. Although previously reported similar experimental animal studies, the aim of this human study is to investigate the expression of TGF-β (1,2,3) and Smads (1,2,3,6,7) in aborted human fetuses with myeloschisis. Material and Methods: Twelve human fetuses with neural tube defect were obtained. They were stained with antibodies against TGF-β1, TGF-β2, TGF-β3, Smad (1,2,3), Smad 6 and Smad 7 using the indirect immunohistochemical technique. Results: We noted mild immune reactivity of TGF-β1 and TGF-β2 in the open neural plate, motor neurons and surrounding tissue. Strong immune reactivity of TGF-β3 was shown in only open neural plate and surrounding tissue. Immunoreactivity of all Smads noted negative except Smad7. ConclusIon: These results suggested at the site where the neural tube failed to close, TGF-β 1,2 and Smads 1,2,3,6 do not continue their activity and decrease with internal timing of embryonic development. Additionally ectodermal layers are considered by embryo as "not closed wound" and TGF-β3 activity may be an effort to repair the failed closure.
dc.identifier.DOI-ID10.5137/1019-5149.JTN.9428-13.0
dc.identifier.issn10195149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17432
dc.language.isoEnglish
dc.publisherTurkish Neurosurgical Society
dc.subjectAdult
dc.subjectColoring Agents
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectNeural Tube
dc.subjectNeural Tube Defects
dc.subjectParaffin Embedding
dc.subjectPregnancy
dc.subjectSignal Transduction
dc.subjectSmad Proteins
dc.subjectTissue Fixation
dc.subjectTransforming Growth Factor beta
dc.subjectcoloring agent
dc.subjectparaffin
dc.subjectSmad protein
dc.subjecttransforming growth factor beta
dc.subjectadult
dc.subjectarticle
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmetabolism
dc.subjectneural tube
dc.subjectneural tube defect
dc.subjectpathology
dc.subjectpregnancy
dc.subjectprenatal development
dc.subjectsignal transduction
dc.subjecttissue fixation
dc.titleTGF-βs and SMADs activities at the site of failed neural tube in the human embryos
dc.typeArticle

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