HALP Score as a New Prognostic Index in Metastatic Renal Cell Cancer
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2022
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Abstract
Objective: To evaluate prognostic significance of the new index, designed by formulating hemoglobin, albumin, lymphocyte, and platelet (HALP) counts in patients with metastatic renal cell carcinoma (RCC). Study Design: Descriptive study. Place and Duration of Study: Department of Medical Oncology, Celal Bayar University, Manisa, Turkey and Adnan Menderes University, Aydin, Turkey, from January 2014 to April 2020. Methodology: Patients with metastatic RCC and sufficient follow-up data were included in the study as a retrospective cohort. HALP score was calculated as hemoglobin (g/L) × albumin (g/L) levels × lymphocyte count (/L)/platelet count (/L). The cut-off value was determined by examining the area under the ROC curve for the HALP value. The endpoints of this study included overall survival (OS) and progression-free survival (PFS). Results: The mean overall survival (OS) of the patients with low HALP score was 17.7 months (95% CI, 2.21 - 33.18), while the OS of the patients with high HALP score was 89.7 months (95% CI, 55.62 - 123.77) and reached statistical significance (p=0.001). The results of univariate (p = 0.009) and multivariate (p=0.012) analyses were statistically significant as well. Conclusion: The HALP score in metastatic RCC patients was closely related to the prognosis. Worse OS was found in patients with a low HALP score. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.
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Albumins , Carcinoma, Renal Cell , Hemoglobins , Humans , Kidney Neoplasms , Lymphocytes , Prognosis , Retrospective Studies , albumin , hemoglobin , albuminoid , hemoglobin , adult , aged , Article , cancer patient , cancer prognosis , cohort analysis , confidence interval , controlled study , descriptive research , diagnostic test accuracy study , female , follow up , hemoglobin albumin lymphocyte and platelet score , human , kidney metastasis , lymphocyte count , major clinical study , male , multivariate analysis , overall survival , platelet count , progression free survival , receiver operating characteristic , retrospective study , scoring system , sensitivity and specificity , statistical significance , Turkey (republic) , univariate analysis , kidney tumor , lymphocyte , prognosis , renal cell carcinoma