Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy

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dc.contributor.authorTanır Basaranoğlu S.
dc.contributor.authorKaraaslan A.
dc.contributor.authorSalı E.
dc.contributor.authorÇiftçi E.
dc.contributor.authorGayretli Aydın Z.G.
dc.contributor.authorAldemir Kocabaş B.
dc.contributor.authorKaya C.
dc.contributor.authorŞen Bayturan S.
dc.contributor.authorKara S.S.
dc.contributor.authorYılmaz Çiftdoğan D.
dc.contributor.authorÇay Ü.
dc.contributor.authorGundogdu Aktürk H.
dc.contributor.authorÇelik M.
dc.contributor.authorOzdemir H.
dc.contributor.authorSomer A.
dc.contributor.authorDiri T.
dc.contributor.authorYazar A.S.
dc.contributor.authorSütçü M.
dc.contributor.authorTezer H.
dc.contributor.authorKaradag Oncel E.
dc.contributor.authorKara M.
dc.contributor.authorÇelebi S.
dc.contributor.authorÖzkaya Parlakay A.
dc.contributor.authorKarakaşlılar S.
dc.contributor.authorArısoy E.S.
dc.contributor.authorTanır G.
dc.contributor.authorTural Kara T.
dc.contributor.authorDevrim İ.
dc.contributor.authorErat T.
dc.contributor.authorAykaç K.
dc.contributor.authorKaba Ö.
dc.contributor.authorGüven Ş.
dc.contributor.authorYeşil E.
dc.contributor.authorTekin Yılmaz A.
dc.contributor.authorYaşar Durmuş S.
dc.contributor.authorÇağlar İ.
dc.contributor.authorGünay F.
dc.contributor.authorÖzen M.
dc.contributor.authorDinleyici E.Ç.
dc.contributor.authorKara A.
dc.date.accessioned2024-07-22T08:02:04Z
dc.date.available2024-07-22T08:02:04Z
dc.date.issued2023
dc.description.abstractBackground: Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region. Methods: The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre. Results: A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect. Conclusion: This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region. © 2023, The Author(s).
dc.identifier.DOI-ID10.1186/s12887-023-03939-w
dc.identifier.issn14712431
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11703
dc.language.isoEnglish
dc.publisherBioMed Central Ltd
dc.rightsAll Open Access; Gold Open Access
dc.subjectAmoxicillin-Potassium Clavulanate Combination
dc.subjectAnti-Bacterial Agents
dc.subjectCephalosporins
dc.subjectChild
dc.subjectDiarrhea
dc.subjectHumans
dc.subjectOutpatients
dc.subjectProspective Studies
dc.subjectamoxicillin plus clavulanic acid
dc.subjectcephalosporin
dc.subjectantiinfective agent
dc.subjectcephalosporin derivative
dc.subjectadolescent
dc.subjectadverse outcome
dc.subjectantibiotic associated diarrhea
dc.subjectantibiotic therapy
dc.subjectArticle
dc.subjectchild
dc.subjectclinical feature
dc.subjectdrug safety
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoutpatient department
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectTurkey (republic)
dc.subjectclinical trial
dc.subjectdiarrhea
dc.subjectmulticenter study
dc.subjectoutpatient
dc.titleAntibiotic associated diarrhea in outpatient pediatric antibiotic therapy
dc.typeArticle

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