Effects of CPAP (Continous positive airway pressure) treatment on oxidative stress and pro-inflammatory process; [CPAP (Continous positive airway pressure) tedavisinin oksidatif stres ve proinflamatuar sürece olan etkisi]

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dc.contributor.authorKisabay A.
dc.contributor.authorSari U.S.
dc.contributor.authorÇakiroğlu Aldemir E.
dc.contributor.authorOktan B.
dc.contributor.authorKorkmaz T.
dc.contributor.authorDinç Horasan G.
dc.contributor.authorYilmaz H.
dc.date.accessioned2024-07-22T08:12:24Z
dc.date.available2024-07-22T08:12:24Z
dc.date.issued2016
dc.description.abstractIntroduction: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for development of atherosclerotic processes because it leads to hypertension, impaired glucose metabolism, obesity and metabolic syndrome, cardiac diseases, elevated blood pressure, and increased level of cholesterol, triglycerides, homocysteine, and coagulation. Materials and Methods: Our aim was to evaluate presence of subclinical atherosclerosis prior to CPAP treatment in the patients with OSAS without any history of previous diseases and any pathological finding in their investigations. After obtaining approval from the Ethics Board, we planned to compare the results of investigations for risk factors for atherosclerosis (fasting blood glucose [FBG], total cholesterol, Triglycerides, HDL- and LDL-cholesterol, thyroid function test, homocysteine, fibrinogen, high sensitivity C-reactive protein [hsCRP]) before and after CPAP treatment and to examine the effect of CPAP treatment on these parameters between July 2013 and July 2015. Findings: Findings obtained before CPAP treatment (homocysteine, hsCRP, HbA1c, subclinical hypothyroidism) suggested subclinical atherosclerosis. In comparative evaluation between the findings before and after CPAP treatment, no statistically significant difference was found in levels of triglycerides, HDL-cholesterol and fT4 (P = 0.346, 0.540, 0.060, respectively) whereas significant differences were found in leukocyte and platelet counts, hemoglobin level, fasting blood glucose, LDL-cholesterol, homocysteine, fibrinogen, fT3, TSH, CRP, and HbA1c (P = 0,003,-0,010,-0,000,-0,001,-0,008-0,004-0,000-0,000-0,025-0,000-0,000-0,000, respectively). Subclinical hypothyroidism was present in 12 (20%) patients before CPAP and in 5 (7%) patients after CPAP treatment. Conclusions: Improvement has been seen even in early markers of atherosclerosis with effective CPAP. © 2016, Ege University Press. All Rights Reserved.
dc.identifier.issn13001817
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16049
dc.language.isoEnglish
dc.publisherEge University Press
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectfibrinogen
dc.subjectglucose
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein
dc.subjecthomocysteine
dc.subjectliothyronine
dc.subjectlow density lipoprotein
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectatherosclerosis
dc.subjectblood analysis
dc.subjectelectrocardiography
dc.subjectfemale
dc.subjecthuman
dc.subjecthypothyroidism
dc.subjectinflammation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoxidative stress
dc.subjectpositive end expiratory pressure
dc.subjectrisk factor
dc.subjectsleep disordered breathing
dc.subjectthyroid function test
dc.subjecttreatment planning
dc.titleEffects of CPAP (Continous positive airway pressure) treatment on oxidative stress and pro-inflammatory process; [CPAP (Continous positive airway pressure) tedavisinin oksidatif stres ve proinflamatuar sürece olan etkisi]
dc.typeArticle

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