Efficacy of AI-Assisted Personalized Microbiome Modulation by Diet in Functional Constipation: A Randomized Controlled Trial

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dc.contributor.authorArslan N.Ç.
dc.contributor.authorGündoğdu A.
dc.contributor.authorTunali V.
dc.contributor.authorTopgül O.H.
dc.contributor.authorBeyazgül D.
dc.contributor.authorNalbantoğlu Ö.U.
dc.date.accessioned2024-07-22T08:04:03Z
dc.date.available2024-07-22T08:04:03Z
dc.date.issued2022
dc.description.abstractBackground: Currently, medications and behavioral modifications have limited success in the treatment of functional constipation (FC). An individualized diet based on microbiome analysis may improve symptoms in FC. In the present study, we aimed to investigate the impacts of microbiome modulation on chronic constipation. Methods: Between December 2020–December 2021, 50 patients fulfilling the Rome IV criteria for functional constipation were randomized into two groups. The control group received sodium picosulfate plus conventional treatments (i.e., laxatives, enemas, increased fiber, and fluid intake). The study group underwent microbiome analysis and received an individualized diet with the assistance of a soft computing system (Enbiosis Biotechnology®, Sariyer, Istanbul). Differences in patient assessment constipation–quality of life (PAC-QoL) scores and complete bowel movements per week (CBMpW) were compared between groups after 6-weeks of intervention. Results: The mean age of the overall cohort (n = 45) was 31.5 ± 10.2 years, with 88.9% female predominance. The customized diet developed for subjects in the study arm resulted in a 2.5-fold increase in CBMpW after 6-weeks (1.7 vs. 4.3). The proportion of the study group patients with CBMpW > 3 was 83% at the end of the study, and the satisfaction score was increased 4-fold from the baseline (3.1 to 10.7 points). More than 50% improvement in PAC-QoL scores was observed in 88% of the study cohort compared to 40% in the control group (p = 0.001). Conclusion: The AI-assisted customized diet based on individual microbiome analysis performed significantly better compared to conventional therapy based on patient-reported outcomes in the treatment of functional constipation. © 2022 by the authors.
dc.identifier.DOI-ID10.3390/jcm11226612
dc.identifier.issn20770383
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12552
dc.language.isoEnglish
dc.publisherMDPI
dc.rightsAll Open Access; Gold Open Access
dc.subjectbisacodyl
dc.subjectenema
dc.subjectlaxative
dc.subjectpicosulfate sodium
dc.subjectRNA 16S
dc.subjectadult
dc.subjectage
dc.subjectArticle
dc.subjectartificial intelligence
dc.subjectchronic constipation
dc.subjectclinical article
dc.subjectclinical effectiveness
dc.subjectcohort analysis
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdiet therapy
dc.subjectdigestive system disease assessment
dc.subjectfemale
dc.subjectfiber intake
dc.subjectfluid intake
dc.subjectfunctional constipation
dc.subjectfunctional disease
dc.subjecthuman
dc.subjectintervention study
dc.subjectintestine flora
dc.subjectintestine sound
dc.subjectmale
dc.subjectPatient Assessment Constipation Quality of Life score
dc.subjectpatient satisfaction
dc.subjectpatient worry
dc.subjectpersonalized nutrition
dc.subjectphysical well-being
dc.subjectprospective study
dc.subjectquality of life
dc.subjectquality of life assessment
dc.subjectrandomized controlled trial
dc.subjectRome IV criteria
dc.subjectsex
dc.subjectsocial well-being
dc.subjectsymbiosis
dc.titleEfficacy of AI-Assisted Personalized Microbiome Modulation by Diet in Functional Constipation: A Randomized Controlled Trial
dc.typeArticle

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