Serum hyaluronic acid levels in patients with ankylosing spondylitis

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dc.contributor.authorDuruöz M.T.
dc.contributor.authorTuran Y.
dc.contributor.authorCerrahoglu L.
dc.contributor.authorIsbilen B.
dc.date.accessioned2024-07-22T08:22:17Z
dc.date.available2024-07-22T08:22:17Z
dc.date.issued2008
dc.description.abstractOur aim in this study was to investigate serum hyaluronic acid (HA) levels and the relationship between clinical parameters in ankylosing spondylitis (AS). Approximately 30 patients with AS and 30 healthy individuals were recruited in this study consecutively. Cross-sectional study was planned, and demographic, clinical, functional, radiological, and laboratory data of patients were evaluated. Disease activity, functional status, and quality of life were assessed, respectively, with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Short-Form 36 (SF-36). Mander Enthesis Index (MEI) was used for evaluation of enthesis involvement. We examined serum concentrations of HA (ng/ml) in patients with AS and controls. The mean ages of patients and control group were 38.3 (SD = 10.8) and 42.7 (SD = 10.6) years, respectively. The mean of serum HA levels in AS patients was 40.4 (SD = 34.8) ng/ml and in controls was 24.9 (SD = 20.2). There was significant difference of HA levels between two groups (p = 0.04). Furthermore, there was a significant correlation between HA level and distance of hand-floor (r = 0.444, p = 0.014), modified lumbar Schober's (r = 0.413, p = 0.023), distance of chin to chest (r = 0.436, p = 0.016), right sacroiliit grade (r = 0.601, p <0.001), left sacroiliit grade (r = 0.610, p <0.001), C reactive protein level (r = 0.404, p = 0.027), albumin (r = 0.464, p = 0.010), C3 (p = 0.449, p = 0.013), and IgA levels (r = 0.369, p = 0.045). However, there was no significant correlation between HA levels with MEI, BASFI, BASDAI, and SF-36 (p ≥0.05). Serum HA level was significantly higher in AS patients than controls. However, there was no significant correlation between serum HA level and disease-specific measures as BASFI and BASDAI; it had significant relation with spinal mobility limitation, sacroiliitis, and laboratory parameters related with acute inflammation. The serum HA level may be a potential biomarker of axial inflammation and disease severity in AS. © Clinical Rheumatology 2007.
dc.identifier.DOI-ID10.1007/s10067-007-0757-0
dc.identifier.issn07703198
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19013
dc.language.isoEnglish
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectHyaluronic Acid
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSacroiliac Joint
dc.subjectSpine
dc.subjectSpondylitis, Ankylosing
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjecthyaluronic acid
dc.subjectnonsteroid antiinflammatory agent
dc.subjectsalazosulfapyridine
dc.subjectadult
dc.subjectankylosing spondylitis
dc.subjectarticle
dc.subjectblood level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdemography
dc.subjectdiagnostic value
dc.subjectdisease activity
dc.subjectdisease severity
dc.subjectfemale
dc.subjectfunctional status
dc.subjecthuman
dc.subjectinflammation
dc.subjectlaboratory test
dc.subjectmale
dc.subjectpriority journal
dc.subjectquality of life
dc.subjectquestionnaire
dc.subjectsacroiliitis
dc.subjectShort Form 36
dc.subjectspine mobility
dc.titleSerum hyaluronic acid levels in patients with ankylosing spondylitis
dc.typeArticle

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