Effect of geldanamycin on the expression of the matrix molecules and angiogenetic factors in a gastric cancer cell line

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dc.contributor.authorGürpinar, T
dc.contributor.authorKosova, F
dc.contributor.authorKurt, FO
dc.contributor.authorCambaz, SU
dc.contributor.authorYücel, AT
dc.contributor.authorUmur, N
dc.contributor.authorTuglu, MI
dc.date.accessioned2025-04-10T10:31:40Z
dc.date.available2025-04-10T10:31:40Z
dc.description.abstractAngiogenesis is the formation of new blood vessels. Angiogenesis affects cancer growth and is a useful target for cancer therapeutics. The effects of geldanamycin on angiogenesis in cases of gastric cancer are poorly understood. We investigated the effects of different doses of 17-allylamino-17-demethoxygeldanamycin (17-AGG), a semi-synthetic derivative of geldanamycin, on the interactions between cellular matrix proteins and angiogenesis factors in a gastric cancer cell line. We examined cancer cells on laminin and collagen I coated surfaces to determine their response to the angiogenic effect of these matrix molecules. We also evaluated the expression levels of VEGF, MMP-9, ES and TSP-1 using ELISA. We found that application of 17-AAG to the gastric cancer cell line on culture dish plastic decreased VEGF, TSP-1, ES and MMP-9 expression, whereas of all of these proteins were increased by laminin and collagen coating. 17-AAG currently is in clinical trial phase 2 and may be a promising drug for treatment of gastric cancer.
dc.identifier.e-issn1473-7760
dc.identifier.issn1052-0295
dc.identifier.urihttp://hdl.handle.net/20.500.14701/38151
dc.language.isoEnglish
dc.titleEffect of geldanamycin on the expression of the matrix molecules and angiogenetic factors in a gastric cancer cell line
dc.typeArticle

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